Isocryptotanshinone
Modify Date: 2024-01-01 19:10:00
Isocryptotanshinone structure
|
Common Name | Isocryptotanshinone | ||
|---|---|---|---|---|
| CAS Number | 22550-15-8 | Molecular Weight | 296.36000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H20O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IsocryptotanshinoneIsocryptotanshinone is a potent signal transducer and activator of transcription 3 (STAT3) and protein tyrosine phosphatase 1B PTP1B inhibitor, with an IC50 of 56.1 μM for PTP1B. |
| Name | Isocryptotanshinon |
|---|---|
| Synonym | More Synonyms |
| Description | Isocryptotanshinone is a potent signal transducer and activator of transcription 3 (STAT3) and protein tyrosine phosphatase 1B PTP1B inhibitor, with an IC50 of 56.1 μM for PTP1B. |
|---|---|
| Related Catalog | |
| Target |
STAT3 PTP1B:56.1 μM (IC50) |
| In Vitro | It is showed that tanshinones significantly inhibited A549 proliferation and Isocryptotanshinone (ICTS) exhibits the strongest activity. Isocryptotanshinone inhibits the constitutive STAT3 and p-STAT3 (Y705) expression in concentration and time-dependent manners. Isocryptotanshinone dramatically inhibits the IL-6-stimulated expression of p-STAT3 (Y705) in a time-dependent manner[1]. |
| References |
| Molecular Formula | C19H20O3 |
|---|---|
| Molecular Weight | 296.36000 |
| Exact Mass | 296.14100 |
| PSA | 43.37000 |
| LogP | 3.59990 |
| Hazard Codes | Xi |
|---|
| 4,4,8-Trimethyl-2,3,8,9-tetrahydro-1H,4H-10-oxa-cyclopenta[b]phenanthrene-7,11-dione |
- Shanghai Nianxing Industrial Co., Ltd
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- China
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- Purity: 98.0%
- Delivery: Inquiry
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- Email: enquiry@dycnchem.com
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Price: ￥7900/5 mg
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