Anti-inflammatory agent 36 structure
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Common Name | Anti-inflammatory agent 36 | ||
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CAS Number | 2293951-01-4 | Molecular Weight | 453.48 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C25H27NO7 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Anti-inflammatory agent 36Anti-inflammatory agent 36 is an anti-inflammatory agent. Anti-inflammatory agent 36 inhibits LPS-induced macrophage activation[1]. |
Name | 2-Piperidinone, 1-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-1-oxo-2-propen-1-yl]-3-[(3,4,5-trimethoxyphenyl)methylene]-, (3E)- |
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Description | Anti-inflammatory agent 36 is an anti-inflammatory agent. Anti-inflammatory agent 36 inhibits LPS-induced macrophage activation[1]. |
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Related Catalog | |
In Vitro | Anti-inflammatory agent 36 (化合物 5a28) (2.5-20 μM) 抑制 LPS 诱导的活化 RAW 264.7 小鼠巨噬细胞中 TNF-α 和 IL-6 的释放,IC50 为 3.69 (TNF-α) 和 3.68 µM (IL-6)[1]。 Anti-inflammatory agent 36 (10 μM,0.5 小时) 抑制 RAW 264.7 小鼠巨噬细胞中 LPS 诱导的 P-P38 和 P-ERK[1]。 Anti-inflammatory agent 36 (10 μM, 0.5 h) 抑制 LPS 诱导的 TNF-α、IL-6、IL-1β、ICAM-1 和 VCAM-1 的转录[1]。 Western Blot Analysis[1] Cell Line: RAW 264.7 mouse macrophages Concentration: 10 μM Incubation Time: 0.5 h Result: Markedly inhibited P-P38 and P-ERK, indicating the suppression of MAPK signaling. |
In Vivo | Anti-inflammatory agent 36 (化合物 5a28) (10 mg/kg,腹腔注射) 抑制急性肺损伤小鼠模型的炎症[1]。 Animal Model: Acute lung injury mouse model[1] Dosage: 10 mg/kg Administration: i.p. Result: Reduced wet/dry weight ratio of the mice lungs. Reduced biomarkers of lymphocytes and macrophages. Suppresses TNF-α, IL-6, IL-1β, 7 VACM-1 and ICAM-1 level. |
References |
Molecular Formula | C25H27NO7 |
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Molecular Weight | 453.48 |