Sinensetin

Modify Date: 2024-01-02 21:06:28

Sinensetin Structure
Sinensetin structure
 Common Name Sinensetin
CAS Number 2306-27-6 Molecular Weight 372.369
Density 1.2±0.1 g/cm3 Boiling Point 547.8±50.0 °C at 760 mmHg
Molecular Formula C20H20O7 Melting Point 174-176ºC
MSDS Chinese USA Flash Point 240.6±30.2 °C
Symbol GHS06
GHS06		 Signal Word Danger

 Use of Sinensetin


Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.In vitro: Sinensetin promots adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels. [1] Sinensetin shows anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α). [2]In vivo: Sinensetin has the most potent antiangiogenesis activity and the lowest toxicity, inhibits angiogenesis by inducing cell cycle arrest in the G0/G1 phase in HUVEC culture and downregulating the mRNA expressions of angiogenesis genes flt1, kdrl, and hras in zebrafish. [3]

 Names

Name sinensetin
Synonym More Synonyms

 Sinensetin Biological Activity

Description Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.In vitro: Sinensetin promots adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels. [1] Sinensetin shows anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α). [2]In vivo: Sinensetin has the most potent antiangiogenesis activity and the lowest toxicity, inhibits angiogenesis by inducing cell cycle arrest in the G0/G1 phase in HUVEC culture and downregulating the mRNA expressions of angiogenesis genes flt1, kdrl, and hras in zebrafish. [3]
Related Catalog
References

[1]. Kang SI et al. Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes. Biol Pharm Bull. 2015;38(4):552-8.

[2]. Shin HS et al. Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α. Biosci Biotechnol Biochem. 2012;76(4):847-9.

[3]. Lam IK et al. In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent. Mol Nutr Food Res. 2012 Jun;56(6):945-56.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 547.8±50.0 °C at 760 mmHg
Melting Point 174-176ºC
Molecular Formula C20H20O7
Molecular Weight 372.369
Flash Point 240.6±30.2 °C
Exact Mass 372.120911
PSA 76.36000
LogP 3.08
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.566
Storage condition 2-8°C

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Hazard Codes T
Risk Phrases 25
Safety Phrases 22-24/25
RIDADR UN 2811 6.1 / PGIII
HS Code 2914509090

 Synthetic Route

 Customs

HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Articles1

More Articles
Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes.

Biol. Pharm. Bull. 38(4) , 552-8, (2015)

Sinensetin is a rare polymethoxylated flavone (PMF) found in certain citrus fruits. In this study, we investigated the effects of sinensetin on lipid metabolism in 3T3-L1 cells. Sinensetin promoted ad...

 Synonyms

6-hydroxyluteolin 5,6,7,3',4'-pentamethyl ether
MFCD00017421
3',4',5,6,7-PENTAMETHOXYFLAVONE
Sinensetin
4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxy-
5,6,7,3',4'-pentamethoxyflavanone
2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-chromen-4-one
Pedalitin permethyl ether
5,6,7,3',4'-Pentamethoxyflavone
2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one
Sinenstein
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Chemsrc provides Sinensetin(CAS#:2306-27-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Sinensetin are included as well.>> amp version: Sinensetin

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