Sinensetin

Modify Date: 2024-01-02 21:06:28

Sinensetin structure	Common Name	Sinensetin
	CAS Number	2306-27-6	Molecular Weight	372.369
	Density	1.2±0.1 g/cm3	Boiling Point	547.8±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₀O₇	Melting Point	174-176ºC
	MSDS	Chinese USA	Flash Point	240.6±30.2 °C
	Symbol	GHS06	Signal Word	Danger

Use of Sinensetin

Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.In vitro: Sinensetin promots adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels. [1] Sinensetin shows anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α). [2]In vivo: Sinensetin has the most potent antiangiogenesis activity and the lowest toxicity, inhibits angiogenesis by inducing cell cycle arrest in the G0/G1 phase in HUVEC culture and downregulating the mRNA expressions of angiogenesis genes flt1, kdrl, and hras in zebrafish. [3]

Name	sinensetin
Synonym	More Synonyms

Description	Sinensetin is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.In vitro: Sinensetin promots adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels. [1] Sinensetin shows anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α). [2]In vivo: Sinensetin has the most potent antiangiogenesis activity and the lowest toxicity, inhibits angiogenesis by inducing cell cycle arrest in the G0/G1 phase in HUVEC culture and downregulating the mRNA expressions of angiogenesis genes flt1, kdrl, and hras in zebrafish. [3]
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> PGE synthase Signaling Pathways >> Apoptosis >> TNF Receptor Natural Products >> Flavonoids Research Areas >> Others
References	[1]. Kang SI et al. Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes. Biol Pharm Bull. 2015;38(4):552-8. [2]. Shin HS et al. Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α. Biosci Biotechnol Biochem. 2012;76(4):847-9. [3]. Lam IK et al. In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent. Mol Nutr Food Res. 2012 Jun;56(6):945-56.

Description

Related Catalog

Signaling Pathways >> Immunology/Inflammation >> PGE synthase

Signaling Pathways >> Apoptosis >> TNF Receptor

Natural Products >> Flavonoids

Research Areas >> Others

References

[1]. Kang SI et al. Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes. Biol Pharm Bull. 2015;38(4):552-8.

[2]. Shin HS et al. Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α. Biosci Biotechnol Biochem. 2012;76(4):847-9.

[3]. Lam IK et al. In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent. Mol Nutr Food Res. 2012 Jun;56(6):945-56.

Density	1.2±0.1 g/cm3
Boiling Point	547.8±50.0 °C at 760 mmHg
Melting Point	174-176ºC
Molecular Formula	C₂₀H₂₀O₇
Molecular Weight	372.369
Flash Point	240.6±30.2 °C
Exact Mass	372.120911
PSA	76.36000
LogP	3.08
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.566
Storage condition	2-8°C

Sinensetin MSDS(Chinese)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Hazard Codes	T
Risk Phrases	25
Safety Phrases	22-24/25
RIDADR	UN 2811 6.1 / PGIII
HS Code	2914509090

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Sinensetin enhances adipogenesis and lipolysis by increasing cyclic adenosine monophosphate levels in 3T3-L1 adipocytes.

Biol. Pharm. Bull. 38(4) , 552-8, (2015)

Sinensetin is a rare polymethoxylated flavone (PMF) found in certain citrus fruits. In this study, we investigated the effects of sinensetin on lipid metabolism in 3T3-L1 cells. Sinensetin promoted ad...

6-hydroxyluteolin 5,6,7,3',4'-pentamethyl ether

MFCD00017421

3',4',5,6,7-PENTAMETHOXYFLAVONE

Sinensetin

4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxy-

5,6,7,3',4'-pentamethoxyflavanone

2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-chromen-4-one

Pedalitin permethyl ether

5,6,7,3',4'-Pentamethoxyflavone

2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one

Sinenstein

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China
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