Microtubule inhibitor PP-13
Modify Date: 2025-08-26 01:01:36
Microtubule inhibitor PP-13 structure
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Common Name | Microtubule inhibitor PP-13 | ||
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| CAS Number | 2324119-74-4 | Molecular Weight | 400.482 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H24N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Microtubule inhibitor PP-13Microtubule inhibitor PP-13 is a novel microtubule-destabilizing agent, directly inhibits microtubule assembly by targeting the colchicine-binding site in β-tubulin.PP-13 inhibits the growth of a wide range of cancer cell types, including targeted therapy-resistant and multidrug-resistant (MDR) cell lines (IC50=76-255 nM).PP-13 overcomes the multidrug-resistant (MDR) phenotype in cancer cells, induces mitotic blockade in cancer cells, interferes with both mitotic microtubule organization and spindle pole integrity.PP-13 induces cell prometaphase arrest then asymmetric division or direct apoptotic death.PP-13 reduces tumour growth and metastasis invasion in vivo. |
| Name | Microtubule inhibitor PP-13 |
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| Description | Microtubule inhibitor PP-13 is a novel microtubule-destabilizing agent, directly inhibits microtubule assembly by targeting the colchicine-binding site in β-tubulin.PP-13 inhibits the growth of a wide range of cancer cell types, including targeted therapy-resistant and multidrug-resistant (MDR) cell lines (IC50=76-255 nM).PP-13 overcomes the multidrug-resistant (MDR) phenotype in cancer cells, induces mitotic blockade in cancer cells, interferes with both mitotic microtubule organization and spindle pole integrity.PP-13 induces cell prometaphase arrest then asymmetric division or direct apoptotic death.PP-13 reduces tumour growth and metastasis invasion in vivo. |
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| References | 1. Pauline Gilson, et al. Sci Rep. 2017 Aug 31;7(1):10209. |
| Molecular Formula | C24H24N4O2 |
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| Molecular Weight | 400.482 |
| InChIKey | CMKYHVHKOFTGEP-UHFFFAOYSA-N |
| SMILES | CCOC(=O)c1ccc(Cn2c(C)cc3c(NCc4ccccc4)ncnc32)cc1 |