2324119-74-4
2324119-74-4 structure
- Name: Microtubule inhibitor PP-13
- Chemical Name: Microtubule inhibitor PP-13
- CAS Number: 2324119-74-4
- Molecular Formula: C24H24N4O2
- Molecular Weight: 400.482
- Create Date: 2022-07-11 23:52:56
- Modify Date: 2024-01-11 08:37:54
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Microtubule inhibitor PP-13 is a novel microtubule-destabilizing agent, directly inhibits microtubule assembly by targeting the colchicine-binding site in β-tubulin.PP-13 inhibits the growth of a wide range of cancer cell types, including targeted therapy-resistant and multidrug-resistant (MDR) cell lines (IC50=76-255 nM).PP-13 overcomes the multidrug-resistant (MDR) phenotype in cancer cells, induces mitotic blockade in cancer cells, interferes with both mitotic microtubule organization and spindle pole integrity.PP-13 induces cell prometaphase arrest then asymmetric division or direct apoptotic death.PP-13 reduces tumour growth and metastasis invasion in vivo.
| Name | Microtubule inhibitor PP-13 |
|---|
| Description | Microtubule inhibitor PP-13 is a novel microtubule-destabilizing agent, directly inhibits microtubule assembly by targeting the colchicine-binding site in β-tubulin.PP-13 inhibits the growth of a wide range of cancer cell types, including targeted therapy-resistant and multidrug-resistant (MDR) cell lines (IC50=76-255 nM).PP-13 overcomes the multidrug-resistant (MDR) phenotype in cancer cells, induces mitotic blockade in cancer cells, interferes with both mitotic microtubule organization and spindle pole integrity.PP-13 induces cell prometaphase arrest then asymmetric division or direct apoptotic death.PP-13 reduces tumour growth and metastasis invasion in vivo. |
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| References | 1. Pauline Gilson, et al. Sci Rep. 2017 Aug 31;7(1):10209. |
| Molecular Formula | C24H24N4O2 |
|---|---|
| Molecular Weight | 400.482 |