Azido-PEG12-NHS ester

Modify Date: 2024-01-09 12:36:30

Azido-PEG12-NHS ester Structure
Azido-PEG12-NHS ester structure
Common Name Azido-PEG12-NHS ester
CAS Number 2363756-50-5 Molecular Weight 740.79
Density N/A Boiling Point N/A
Molecular Formula C31H56N4O16 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Azido-PEG12-NHS ester


Azido-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Azido-PEG12-NHS ester

 Azido-PEG12-NHS ester Biological Activity

Description Azido-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C31H56N4O16
Molecular Weight 740.79