Boc-C1-PEG3-C4-OBn

Modify Date: 2024-01-20 17:52:04

Boc-C1-PEG3-C4-OBn Structure
Boc-C1-PEG3-C4-OBn structure
Common Name Boc-C1-PEG3-C4-OBn
CAS Number 2381196-81-0 Molecular Weight 410.54
Density N/A Boiling Point N/A
Molecular Formula C23H38O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Boc-C1-PEG3-C4-OBn


Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader-1 (HY-125878). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

 Names

Name Boc-C1-PEG3-C4-OBn

 Boc-C1-PEG3-C4-OBn Biological Activity

Description Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader-1 (HY-125878). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Related Catalog
Target

PEGs

References

[1]. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTACDegrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.

 Chemical & Physical Properties

Molecular Formula C23H38O6
Molecular Weight 410.54
Storage condition -20°C