Gentisic acid

Modify Date: 2025-08-20 12:57:49

Gentisic acid structure	Common Name	Gentisic acid
	CAS Number	490-79-9	Molecular Weight	154.120
	Density	1.6±0.1 g/cm3	Boiling Point	406.9±35.0 °C at 760 mmHg
	Molecular Formula	C₇H₆O₄	Melting Point	204-208 °C(lit.)
	MSDS	Chinese USA	Flash Point	214.0±22.4 °C
	Symbol	GHS07	Signal Word	Warning

Use of Gentisic acid

2,5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors.

Name	2,5-dihydroxybenzoic acid
Synonym	More Synonyms

Description	2,5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR Natural Products >> Acids and Aldehydes Research Areas >> Others
Target	Human Endogenous Metabolite Fibroblast growth factor
In Vitro	2,5-Dihydroxybenzoic acid (Gentisic acid) is a derivative of benzoic and a minor product of the metabolic break down of aspirin[1]. 2,5-Dihydroxybenzoic acid is also a component of many traditional liquors and herbal remedies, is singled out as a powerful inhibitor of fibroblast growth factors. 2,5-Dihydroxybenzoic acid is used as a lead to identify additional compounds with better inhibitory characteristics generating a new chemical class of fibroblast growth factor inhibitors that includes the agent responsible for alkaptonuria. Through low and high resolution approaches, using representative members of the fibroblast growth factor family and their cell receptors, it is shown that this class of inhibitors may employ two different mechanisms to interfere with the assembly of the signaling complexes that trigger fibroblast growth factor-driven mitogenesis[2].
In Vivo	It is verified from in vivo disease models that this group of inhibitors (e.g., 2,5-Dihydroxybenzoic acid) may be of interest to treat cancer and angiogenesis-dependent diseases[2].
References	[1]. Levy G, et al. Salicylate accumulation kinetics in man. N Engl J Med. 1972 Aug 31;287(9):430-2. [2]. IS Fernández, et al. Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. Journal of Biological Chemistry , 2010, 285(15):11714-29.

Density	1.6±0.1 g/cm3
Boiling Point	406.9±35.0 °C at 760 mmHg
Melting Point	204-208 °C(lit.)
Molecular Formula	C₇H₆O₄
Molecular Weight	154.120
Flash Point	214.0±22.4 °C
Exact Mass	154.026611
PSA	77.76000
LogP	1.56
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.671
InChIKey	WXTMDXOMEHJXQO-UHFFFAOYSA-N
SMILES	O=C(O)c1cc(O)ccc1O
Water Solubility	soluble

Gentisic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LY3850000

CHEMICAL NAME :: Gentisic acid

CAS REGISTRY NUMBER :: 490-79-9

BEILSTEIN REFERENCE NO. :: 2209119

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C7-H6-O4

MOLECULAR WEIGHT :: 154.13

WISWESSER LINE NOTATION :: QVR BQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 374 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 380 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 642 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 1 mmol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 29,1275,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2841 No. of Facilities: 22 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 38 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2841 No. of Facilities: 39 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 259 (estimated) No. of Female Employees: 60 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LY3850000
HS Code	29182990

Precursor 10
CAS#:50-79-3 2,5-Dichloroben... CAS#:89-55-4 5-Bromo-2-hydro... CAS#:123-31-9 Hydroquinone CAS#:10590-85-9 2-(β-D-Glucopyr...
CAS#:69-72-7 Salicylic acid CAS#:298-14-6 Potassium hydro... CAS#:2785-98-0 2,5-Dimethoxybe... CAS#:2612-02-4 5-Methoxysalicy...
CAS#:65-85-0 benzoic acid CAS#:1201-38-3 1-(2,5-Dimethox...
DownStream 10
CAS#:1084-96-4 Benzoic acid,2,... CAS#:2150-41-6 METHYL 2,4-DIME... CAS#:606-45-1 Methyl 2-methox... CAS#:5368-81-0 Methyl 3-methox...
CAS#:121-98-2 Methyl anisate CAS#:2150-38-1 Methyl 3,4-dime... CAS#:1916-07-0 Trimethylgallic... CAS#:2150-42-7 Benzoic acid,2,...
CAS#:2150-40-5 methyl 2,5-dime... CAS#:2150-37-0 Methyl 3,5-dime...

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase.

Nat. Commun. 6 , 5961, (2015)

Lytic polysaccharide monooxygenases (LPMOs) are recently discovered enzymes that oxidatively deconstruct polysaccharides. LPMOs are fundamental in the effective utilization of these substrates by bact...

Antimicrobial activity of natural products from the flora of Northern Ontario, Canada.

Pharm. Biol. 53(6) , 800-6, (2015)

The number of multidrug resistant (MDR) microorganisms is increasing and the antimicrobial resistance expressed by these pathogens is generating a rising global health crisis. In fact, there are only ...

Comparison of Mannose, Ethylene Glycol, and Methoxy-Terminated Diluents on Specificity and Selectivity of Electrochemical Peptide-Based Sensors.

Anal. Chem. 87 , 6966-73, (2015)

We report the synthesis and application of three new antifouling diluents for the fabrication of an E-PB HIV sensor. Among the three thiolated antifouling diluents used in this study, the methoxy-term...

Name: Binding affinity towards human GABRA1 in an in vitro assay with cellular components m...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit gamma-2
External Id: CHEMBL5291799

Name: Increase in membrane potential in mollusc neurons assessed as conductance of potassiu...
Source: ChEMBL
Target: Neuron
External Id: CHEMBL3283149

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur...
Source: ChEMBL
Target: Estrogen receptor
External Id: CHEMBL5291792

Name: Compound was evaluated for inhibition of human F2 in an in vitro cell free assay meas...
Source: ChEMBL
Target: Prothrombin
External Id: CHEMBL5291794

Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity

Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

Name: Octanol-water partition coefficient, log P of the compound
Source: ChEMBL
Target: N/A
External Id: CHEMBL3283138

Total 165, Current Page 1 of 17

Benzoic acid,2,5-dihydroxy

Gentistic acid

Gensigon

2,5-dihydroxyphenylcarboxylic acid

2,5-DHBA,DHB,Gentisic acid

Gensigen

2,5-Dihydroxybenzoic acid

Gentisate

2,5-Dhba

Hydroquinonecarboxylic acid

2,5-dihydroxybenzoate

5-Hydroxysalicylic acid

EINECS 207-718-5

2,5-Dioxybenzoic acid

5-hydroxy-Salicylic acid

MFCD00002460

2,5-Dihydroxy-benzoic acid

gentisic acid

3,6-Dihydroxybenzoic Acid

2,5-dihydroxy benzoic acid

Carboxyhydroquinone

DHB

Mesalazine Impurity 7

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Gentisic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Gentisic acid
Price: ￥Inquiry/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,5-Dihydroxybenzoic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Gentisic acid
Price: ￥298.0/20mg ￥405.0/100g ￥135.0/25g
Purity: 98.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

naturewill
China
Product Name: Gentisic acid
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Bella
Email: 3157321941@qq.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2,5-Dihydroxybenzoesäure
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Get all suppliers and price by the below link:

Gentisic acid suppliers

Price: ￥109.2/25g

Reference only. check more Gentisic acid price

Gentisic acid

Use of Gentisic acid

Names

Gentisic acid Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Articles259

Gentisic acidBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.