m-PEG10-acid

Modify Date: 2024-01-12 06:30:41

m-PEG10-acid structure	Common Name	m-PEG10-acid
	CAS Number	2409969-94-2	Molecular Weight	500.58
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₄₄O₁₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of m-PEG10-acid

m-PEG10-acid is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Name	m-PEG10-acid

Description	m-PEG10-acid is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. John F. Donovan et al. Pegylated prodrugs of phenolic trpv1 agonists. WO2020023794A1. [2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Molecular Formula	C₂₂H₄₄O₁₂
Molecular Weight	500.58
Storage condition	2-8°C