Influenza virus-IN-3

Modify Date: 2024-04-05 18:05:10

Influenza virus-IN-3 structure	Common Name	Influenza virus-IN-3
	CAS Number	2412451-16-0	Molecular Weight	456.60
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₃₂N₂O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Influenza virus-IN-3

Influenza virus-IN-3 (compound 9) is a potent and selective influenza virus inhibitor with IC50s of 0.88, 0.10, 5.5, 0.51 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-3 shows antiviral and NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-3 shows low cytotoxicity with an CC50 of >200 µM[1].

Name	Influenza virus-IN-3

Description	Influenza virus-IN-3 (compound 9) is a potent and selective influenza virus inhibitor with IC50s of 0.88, 0.10, 5.5, 0.51 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-3 shows antiviral and NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-3 shows low cytotoxicity with an CC50 of >200 µM[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Inflammation/Immunology
Target	IC50: 0.88 µM (H5N1); 0.10 µM (H5N2); 5.5 µM (H5N6); 0.51 µM (H5N8)[1]
In Vitro	Influenza virus-IN-3 (compound 9a) shows NA (neuraminidase enzyme)-inhibitory activity with IC50s of 118.17, 1442.6, 34543.33, 78.06, 10206, 0.00048, 0.01222 nM for H5N1, H5N2, H5N6, H5N8, H5N1eH274Y, N1 (H1N1pdm09) and N2 (H3N2), respectively[1].
References	[1]. Ai W, et al. Discovery of novel "Dual-site" binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors. Eur J Med Chem. 2020 Apr 1;191:112147.

Molecular Formula	C₂₅H₃₂N₂O₄S
Molecular Weight	456.60

Influenza virus-IN-3

Use of Influenza virus-IN-3

Names

Influenza virus-IN-3 Biological Activity

Chemical & Physical Properties