Influenza A virus-IN-7
Influenza A virus-IN-7 structure
|
Common Name | Influenza A virus-IN-7 | ||
|---|---|---|---|---|
| CAS Number | 2464415-40-3 | Molecular Weight | 459.54 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H25N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Influenza A virus-IN-7Influenza A virus-IN-7 (compound 16r) is a potent and orally active influenza A virus inhibitor with an IC50 of 3.43 µM and CC50 of >100 µM. Influenza A virus-IN-7 shows anti-IAV activity with low cytotoxicity. Influenza A virus-IN-7 inhibits the transcription and replication of viral RNA[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Influenza A virus-IN-7 |
|---|
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Influenza A virus-IN-7 (compound 16r) is a potent and orally active influenza A virus inhibitor with an IC50 of 3.43 µM and CC50 of >100 µM. Influenza A virus-IN-7 shows anti-IAV activity with low cytotoxicity. Influenza A virus-IN-7 inhibits the transcription and replication of viral RNA[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 3.43 µM (influenza virus); CC50: >100 µM (influenza virus)[1] |
| In Vivo | Influenza A virus-IN-7 (compound 16r) (1.25 mg/kg for i.v.; 25 mg/kg for p.o.) shows good PK profiles with oral bioavailability of 22.5%[1]. Animal Model: Male SD rats[1] Dosage: 1.25, 25 mg/kg Administration: I.v. or p.o Result: Showed good PK profiles with oral bioavailability of 22.5%. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C29H25N5O |
|---|---|
| Molecular Weight | 459.54 |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
|
Name: Cytotoxicity against human HEK293T cells assessed as reduction in cell viability afte...
Source: ChEMBL
Target: HEK-293T
External Id: CHEMBL4773826
|
|
Name: Selectivity index, ratio of CC50 for human HEK293T cells to IC50 for Influenza A viru...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4773827
|
|
Name: Antiviral activity against Influenza A virus A/WSN/33(H1N1) infected in HEK293T-Gluc ...
Source: ChEMBL
Target: Influenza A virus
External Id: CHEMBL4773825
|
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the uses of Influenza A virus-IN-7? |
| A: Main uses of Influenza A virus-IN-7: Influenza A virus-IN-7 (compound 16r) is a potent and orally active influenza A virus inhibitor with an IC50 of 3.43 µM and CC50 of >100 µM. Influenza A virus-IN-7 shows anti-IAV activity with low cytotoxicity. Influenza A virus-IN-7 inhibits the transcription and replication of viral RNA[1]. |
| Q: What is the CAS number of Influenza A virus-IN-7? |
| A: CAS number of Influenza A virus-IN-7 is 2464415-40-3. |
| Q: What is the molecular formula of Influenza A virus-IN-7? |
| A: Molecular formula of Influenza A virus-IN-7 is C29H25N5O. |
| Q: What is the Chinese name of 2464415-40-3? |
| A: Chinese name of 2464415-40-3 is 2464415-40-3. |
| Q: What is the English name of Influenza A virus-IN-7? |
| A: The English name of Influenza A virus-IN-7 is Influenza A virus-IN-7. |
| Q: What is the molecular weight of Influenza A virus-IN-7? |
| A: Molecular weight of Influenza A virus-IN-7 is 459.54. |