Influenza A virus-IN-7

Modify Date: 2025-09-02 11:58:20

Influenza A virus-IN-7 Structure
Influenza A virus-IN-7 structure
Common Name Influenza A virus-IN-7
CAS Number 2464415-40-3 Molecular Weight 459.54
Density N/A Boiling Point N/A
Molecular Formula C29H25N5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Influenza A virus-IN-7


Influenza A virus-IN-7 (compound 16r) is a potent and orally active influenza A virus inhibitor with an IC50 of 3.43 µM and CC50 of >100 µM. Influenza A virus-IN-7 shows anti-IAV activity with low cytotoxicity. Influenza A virus-IN-7 inhibits the transcription and replication of viral RNA[1].

 Names

Name Influenza A virus-IN-7

 Influenza A virus-IN-7 Biological Activity

Description Influenza A virus-IN-7 (compound 16r) is a potent and orally active influenza A virus inhibitor with an IC50 of 3.43 µM and CC50 of >100 µM. Influenza A virus-IN-7 shows anti-IAV activity with low cytotoxicity. Influenza A virus-IN-7 inhibits the transcription and replication of viral RNA[1].
Related Catalog
Target

IC50: 3.43 µM (influenza virus); CC50: >100 µM (influenza virus)[1]

In Vivo Influenza A virus-IN-7 (compound 16r) (1.25 mg/kg for i.v.; 25 mg/kg for p.o.) shows good PK profiles with oral bioavailability of 22.5%[1]. Animal Model: Male SD rats[1] Dosage: 1.25, 25 mg/kg Administration: I.v. or p.o Result: Showed good PK profiles with oral bioavailability of 22.5%.
References

[1]. Zhang G, et al. Design, synthesis and in vitro anti-influenza A virus evaluation of novel quinazoline derivatives containing S-acetamide and NH-acetamide moieties at C-4. Eur J Med Chem. 2020 Nov 15;206:112706.

 Chemical & Physical Properties

Molecular Formula C29H25N5O
Molecular Weight 459.54
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