Mt KARI-IN-4

Modify Date: 2024-01-15 19:04:36

Mt KARI-IN-4 structure	Common Name	Mt KARI-IN-4
	CAS Number	2413974-53-3	Molecular Weight	365.36
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₈FN₅O₃S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Mt KARI-IN-4

Mt KARI-IN-4 (compound 5c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 5.48 μM. Mt KARI-IN-4 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 72 μg/mL)[1].

Name	Mt KARI-IN-4

Description	Mt KARI-IN-4 (compound 5c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 5.48 μM. Mt KARI-IN-4 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 72 μg/mL)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Ki: 5.48 μM (Mtb KARI)[1]
References	[1]. Krishna VS, et al. Design and development of ((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. Eur J Med Chem. 2020;193:112178.

Molecular Formula	C₁₃H₈FN₅O₃S₂
Molecular Weight	365.36

Mt KARI-IN-4

Use of Mt KARI-IN-4

Names

Mt KARI-IN-4 Biological Activity

Chemical & Physical Properties