Mt KARI-IN-5

Modify Date: 2024-01-17 14:18:51

Mt KARI-IN-5 structure	Common Name	Mt KARI-IN-5
	CAS Number	2413974-69-1	Molecular Weight	410.45
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₀N₄O₅S₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Mt KARI-IN-5

Mt KARI-IN-5 (compound 6c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 4.72 μM. Mt KARI-IN-5 has inhibitory activity against Mtb H37Rv (MIC = 1.56 μM) and low cytotoxicity (HEK IC50 > 64 μg/mL)[1]

Name	Mt KARI-IN-5

Description	Mt KARI-IN-5 (compound 6c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 4.72 μM. Mt KARI-IN-5 has inhibitory activity against Mtb H37Rv (MIC = 1.56 μM) and low cytotoxicity (HEK IC50 > 64 μg/mL)[1]
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Ki: 4.72 μM (Mtb KARI)[1]
References	[1]. Krishna VS, et al. Design and development of ((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. Eur J Med Chem. 2020;193:112178.

Molecular Formula	C₁₄H₁₀N₄O₅S₃
Molecular Weight	410.45

Mt KARI-IN-5

Use of Mt KARI-IN-5

Names

Mt KARI-IN-5 Biological Activity

Chemical & Physical Properties