RET V804M-IN-1

Modify Date: 2024-09-22 17:50:28

RET V804M-IN-1 Structure
RET V804M-IN-1 structure
Common Name RET V804M-IN-1
CAS Number 2414909-94-5 Molecular Weight 344.37
Density 1.38±0.1 g/cm3(Predicted) Boiling Point N/A
Molecular Formula C19H16N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RET V804M-IN-1


RET V804M-IN-1 (compound 5) is a wt-RET -selective inhibitors of RETV804M kinase, with an IC50 of 20 nM[1].

 Names

Name RET V804M-IN-1

 RET V804M-IN-1 Biological Activity

Description RET V804M-IN-1 (compound 5) is a wt-RET -selective inhibitors of RETV804M kinase, with an IC50 of 20 nM[1].
Related Catalog
Target

IC50: 20 nM (RETV804M)[1].

In Vitro RET V804M-IN-1 (compound 5) exhibits 3.7 and 110 fold selectivity compared to wt-RET and KDR, respectively[1].
References

[1]. Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505.

 Chemical & Physical Properties

Density 1.38±0.1 g/cm3(Predicted)
Molecular Formula C19H16N6O
Molecular Weight 344.37
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Price: ¥1430/10 mM * 1  mL in DMSO

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