terameprocol

Modify Date: 2024-01-02 12:45:15

terameprocol structure	Common Name	terameprocol
	CAS Number	24150-24-1	Molecular Weight	358.471
	Density	1.0±0.1 g/cm3	Boiling Point	458.5±40.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₃₀O₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	108.8±34.2 °C
	Symbol	GHS09	Signal Word	Warning

Use of terameprocol

Terameprocol is a synthetic derivative of Nordihydroguaiaretic acid and a non-selective lipoxygenase inhibitor. Terameprocol has antiviral and antitumor effects[1][2][3].

Name	meso-tetra-O-methyl nordihydroguaiaretic acid
Synonym	More Synonyms

Description	Terameprocol is a synthetic derivative of Nordihydroguaiaretic acid and a non-selective lipoxygenase inhibitor. Terameprocol has antiviral and antitumor effects[1][2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
References	[1]. Hwu JR, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation. J Med Chem. 1998 Jul 30;41(16):2994-3000. [2]. Chen H, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA. J Med Chem. 1998 Jul 30;41(16):3001-7. [3]. Park R, et al. Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors. Clin Cancer Res. 2005 Jun 15;11(12):4601-9.

Description

Terameprocol is a synthetic derivative of Nordihydroguaiaretic acid and a non-selective lipoxygenase inhibitor. Terameprocol has antiviral and antitumor effects[1][2][3].

Related Catalog

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

References

[1]. Hwu JR, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation. J Med Chem. 1998 Jul 30;41(16):2994-3000.

[2]. Chen H, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA. J Med Chem. 1998 Jul 30;41(16):3001-7.

[3]. Park R, et al. Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors. Clin Cancer Res. 2005 Jun 15;11(12):4601-9.

Density	1.0±0.1 g/cm3
Boiling Point	458.5±40.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₀O₄
Molecular Weight	358.471
Flash Point	108.8±34.2 °C
Exact Mass	358.214417
PSA	36.92000
LogP	5.86
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.522

Symbol	GHS09
Signal Word	Warning
Hazard Statements	H410
Precautionary Statements	P273-P501
RIDADR	UN 3077 9 / PGIII

Precursor 6
CAS#:1050512-02-1 erythro-nordihy... CAS#:77-78-1 Dimethyl sulfate CAS#:278808-09-6 (Z)-4,4'-(2,3-d... CAS#:120-14-9 veratraldehyde
CAS#:776-99-8 3,4-Dimethoxyph... CAS#:335327-93-0 1,4-bis(3,4-dim...
DownStream 1
CAS#:1050512-02-1 erythro-nordihy...

Terameprocol, a novel site-specific transcription inhibitor with anticancer activity.

Drugs 3rd ed., 11 , 204-214, (2008)

Terameprocol, a novel, semisynthetic derivative of a naturally occurring plant lignan, is under development by Erimos Pharmaceuticals LLC for the potential treatment of cancer. The antitumor activity ...

Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01.

PLoS ONE 11 , e0148685, (2016)

The ability of Tetra-O-methyl nordihydroguaiaretic acid (M4N) to induce rapid cell death in combination with Etoposide, Rapamycin, or UCN-01 was examined in LNCaP cells, both in cell culture and anima...

Synthesis of apolipoprotein B lipoparticles to deliver hydrophobic/amphiphilic materials.

ACS Appl. Mater. Interfaces 5 , 7509-16, (2013)

To develop a drug delivery system (DDS), it is critical to address challenging tasks such as the delivery of hydrophobic and amphiphilic compounds, cell uptake, and the metabolic fate of the drug deli...

terameprocol

tetramethyl Nordihydroguaiaretic Acid Exclusive

4-[(2R,3S)-4-(3,4-Dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxybenzene

tetramethyl Nordihydroguaiaretic Acid

Benzene, 4-[(2R,3S)-4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxy-

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: tetramethyl Nordihydroguaiaretic Acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: tetramethyl-nordihydroguaiaretic acid
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: tetramethyl-nordihydroguaiaretic acid
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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