terameprocol

更新时间：2024-01-02 12:45:15

terameprocol结构式	常用名	terameprocol	英文名	terameprocol
	CAS号	24150-24-1	分子量	358.471
	密度	1.0±0.1 g/cm3	沸点	458.5±40.0 °C at 760 mmHg
	分子式	C₂₂H₃₀O₄	熔点	N/A
	MSDS	中文版美版	闪点	108.8±34.2 °C
	符号	GHS09	信号词	Warning

terameprocol用途

Terameprocol是去甲二氢愈创木酸的合成衍生物,是一种非选择性脂氧合酶抑制剂。Terameprocol具有抗病毒和抗肿瘤作用[1][2][3]。

英文名	meso-tetra-O-methyl nordihydroguaiaretic acid
英文别名	更多

描述	Terameprocol是去甲二氢愈创木酸的合成衍生物,是一种非选择性脂氧合酶抑制剂。Terameprocol具有抗病毒和抗肿瘤作用[1][2][3]。
相关类别	研究领域 >> 癌症研究领域 >> 感染信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶
参考文献	[1]. Hwu JR, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation. J Med Chem. 1998 Jul 30;41(16):2994-3000. [2]. Chen H, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA. J Med Chem. 1998 Jul 30;41(16):3001-7. [3]. Park R, et al. Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors. Clin Cancer Res. 2005 Jun 15;11(12):4601-9.

描述

Terameprocol是去甲二氢愈创木酸的合成衍生物,是一种非选择性脂氧合酶抑制剂。Terameprocol具有抗病毒和抗肿瘤作用[1][2][3]。

相关类别

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶

参考文献

[1]. Hwu JR, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation. J Med Chem. 1998 Jul 30;41(16):2994-3000.

[2]. Chen H, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA. J Med Chem. 1998 Jul 30;41(16):3001-7.

[3]. Park R, et al. Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors. Clin Cancer Res. 2005 Jun 15;11(12):4601-9.

密度	1.0±0.1 g/cm3
沸点	458.5±40.0 °C at 760 mmHg
分子式	C₂₂H₃₀O₄
分子量	358.471
闪点	108.8±34.2 °C
精确质量	358.214417
PSA	36.92000
LogP	5.86
蒸汽压	0.0±1.1 mmHg at 25°C
折射率	1.522
储存条件	-20°C，密闭，干燥

符号	GHS09
信号词	Warning
危害声明	H410
警示性声明	P273-P501
危险品运输编码	UN 3077 9 / PGIII

terameprocol上游产品 6
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terameprocol下游产品 1
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Terameprocol, a novel site-specific transcription inhibitor with anticancer activity.

Drugs 3rd ed., 11 , 204-214, (2008)

Terameprocol, a novel, semisynthetic derivative of a naturally occurring plant lignan, is under development by Erimos Pharmaceuticals LLC for the potential treatment of cancer. The antitumor activity ...

Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01.

PLoS ONE 11 , e0148685, (2016)

The ability of Tetra-O-methyl nordihydroguaiaretic acid (M4N) to induce rapid cell death in combination with Etoposide, Rapamycin, or UCN-01 was examined in LNCaP cells, both in cell culture and anima...

Synthesis of apolipoprotein B lipoparticles to deliver hydrophobic/amphiphilic materials.

ACS Appl. Mater. Interfaces 5 , 7509-16, (2013)

To develop a drug delivery system (DDS), it is critical to address challenging tasks such as the delivery of hydrophobic and amphiphilic compounds, cell uptake, and the metabolic fate of the drug deli...

terameprocol

tetramethyl Nordihydroguaiaretic Acid Exclusive

4-[(2R,3S)-4-(3,4-Dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxybenzene

tetramethyl Nordihydroguaiaretic Acid

Benzene, 4-[(2R,3S)-4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxy-