NFAT Transcription Factor Regulator

Modify Date: 2024-01-05 12:11:02

NFAT Transcription Factor Regulator structure	Common Name	NFAT Transcription Factor Regulator
	CAS Number	245747-71-1	Molecular Weight	416.28
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₀F₆N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NFAT Transcription Factor Regulator

NFAT Transcription Factor Regulator is an IL-2 synthesis inhibitor with an IC50 of 182 nM.

Name	NFAT Transcription Factor Regulator

Description	NFAT Transcription Factor Regulator is an IL-2 synthesis inhibitor with an IC50 of 182 nM.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology
Target	IC50: 182 nM (IL-2 synthesis)[1]
In Vitro	NFAT Transcription Factor Regulator is compound example 19. NFAT Transcription Factor Regulator inhibits IL-2 synthesis with an IC50 of 182 nM. It inhibits human and rat PBMC proliferation with IC50s of 82 and 146 nM, respectively. It is able to inhibit IL-4 and IL-5 production in human T-cell lines with similar potency to its effects on IL-2 release[1].
In Vivo	NFAT Transcription Factor Regulator is found to have an inhibitory potency approximately 10-fold better than that of cyclosporine. Comparable inhibitory effects on T-cell IL-2 production are obtained with NFAT Transcription Factor Regulator and cyclosporine at doses of 3.0 and 30 mg/kg, po, respectively. The efficacies achieved in monkeys in vivo for blocking T-cell cytokine production suggest that NFAT Transcription Factor Regulator has potential similar to that of cyclosporine for use in transplantation[1].
Animal Admin	Monkey[1] Cynomolgus monkeys are bled to obtain heparinized baseline samples for measuring predrug cytokine production and then briefly intubated for intragastric dosing. Cyclosporine is administered in the Neoral formulation. Compound 19 is given. Postdrug blood samples are similarly obtained 2 h later. The samples are stimulated by spiking undiluted blood with PMA (50 ng/mL) and ionomycin (1µg/mL) and incubating for 24 h. Plasma samples are collected by centrifugation, and IL-2 concentrations are determined by ELISA using recombinant human IL-2 as standard[1].
References	[1]. Djuric SW, et al. 3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator. J Med Chem. 2000 Aug 10;43(16):2975-81.

Molecular Formula	C₁₇H₁₀F₆N₄O₂
Molecular Weight	416.28

DC Chemicals Limited
China
Product Name: NFAT Transcription Factor Regulator
Price: $950.0/100mg $1900.0/250mg $3800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥3850/10 mM * 1 mL in DMSO

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