Lenalidomide-6-F

Modify Date: 2025-08-25 13:04:42

Lenalidomide-6-F Structure
Lenalidomide-6-F structure
Common Name Lenalidomide-6-F
CAS Number 2468780-87-0 Molecular Weight 262.24
Density N/A Boiling Point N/A
Molecular Formula C13H11FN2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Lenalidomide-6-F


Lenalidomide-6-F is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-6-F can be connected to the ligand for protein by a linker to form PROTAC[1].

 Names

Name Lenalidomide-6-F

 Lenalidomide-6-F Biological Activity

Description Lenalidomide-6-F is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-6-F can be connected to the ligand for protein by a linker to form PROTAC[1].
Related Catalog
Target

Cereblon

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Molecular Formula C13H11FN2O3
Molecular Weight 262.24

 Safety Information

Hazard Codes Xi
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