Desethyl chloroquine diphosphate

Modify Date: 2025-08-25 19:53:06

Desethyl chloroquine diphosphate structure	Common Name	Desethyl chloroquine diphosphate
	CAS Number	247912-76-1	Molecular Weight	487.80900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₂₈ClN₃O₈P₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Desethyl chloroquine diphosphate

Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine diphosphate possesses antiplasmodic activity[1][2].

Name	4-N-(7-chloroquinolin-4-yl)-1-N-ethylpentane-1,4-diamine,phosphoric acid
Synonym	More Synonyms

Description	Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine diphosphate possesses antiplasmodic activity[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Infection Signaling Pathways >> Autophagy >> Autophagy
Target	P. falciparum[1]
In Vivo	Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame[3].
References	[1]. Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100. [2]. Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3(2):159-74. [3]. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.

Molecular Formula	C₁₆H₂₈ClN₃O₈P₂
Molecular Weight	487.80900
Exact Mass	487.10400
PSA	212.09000
LogP	2.68500
InChIKey	PIKNKEKUPZTKFZ-UHFFFAOYSA-N
SMILES	CCNCCCC(C)Nc1ccnc2cc(Cl)ccc12.O=P(O)(O)O.O=P(O)(O)O

1,4-Pentanediamine,N4-(7-chloro-4-quinolinyl)-N1-ethyl-,phosphate (1:2)

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Desethyl chloroquine diphosphate

Use of Desethyl chloroquine diphosphate

Names

Desethyl chloroquine diphosphate Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.