Urotensin II (human) trifluoroacetate salt

Modify Date: 2024-01-08 02:04:36

Urotensin II (human) trifluoroacetate salt Structure
Urotensin II (human) trifluoroacetate salt structure
Common Name Urotensin II (human) trifluoroacetate salt
CAS Number 251293-28-4 Molecular Weight 1388.57
Density N/A Boiling Point N/A
Molecular Formula C64H85N13O18S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Urotensin II (human) trifluoroacetate salt


Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

 Names

Name Urotensin II (human)
Synonym More Synonyms

  Biological Activity

Description Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
Related Catalog
Target

GPR14[1]

In Vitro Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC50=0:62±0.17 nM, n=6)[1].
In Vivo Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction[1].
References

[1]. Ames RS, et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature. 1999 Sep 16;401(6750):282-6.

 Chemical & Physical Properties

Molecular Formula C64H85N13O18S2
Molecular Weight 1388.57
PSA 580.00000
LogP 2.88900

 Synonyms

m.w. 1388.57 c64h85n13o18s2
glu-thr-pro-asp-cys-phe-trp-lys-tyr-cys-val hydrochloride
glu-thr-pro-asp-cys-phe-trp-lys-tyr-cys-val
urotensin-ii
h-glu-thr-pro-asp-cys-phe-trp-lys-tyr-cys-val-oh
GLU-THR-PRO-ASP-CYS-PHE-TRP-LYS-TYR-CYS-VAL(DISULFIDE BRIDGE:CYS5-CYS10)
Urotensin II (114-124), human
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