1,6,7-Trihydroxy-9H-xanthen-9-one

Modify Date: 2024-01-11 12:38:18

1,6,7-Trihydroxy-9H-xanthen-9-one structure	Common Name	1,6,7-Trihydroxy-9H-xanthen-9-one
	CAS Number	25577-04-2	Molecular Weight	244.20
	Density	1.6±0.1 g/cm3	Boiling Point	509.2±50.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₈O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	204.8±23.6 °C

Use of 1,6,7-Trihydroxy-9H-xanthen-9-one

1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16[1].

Name	1,6,7-trihydroxyxanthen-9-one
Synonym	More Synonyms

Description	1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	1,6,7-Trihydroxyxanthone (0-10 µg/mL; 0-72 h) 抑制 HepG2、Bel7404 细胞的细胞增殖[1]。 1,6,7-Trihydroxyxanthone (5 µg/mL; 72 h) 诱导 HepG2 细胞凋亡[1]. 1,6,7-Trihydroxyxanthone 降低 Bmi-1 表达并增加 P14、P16 的蛋白表达水平[1]。 1,6,7-Trihydroxyxanthone 在 HepG2、Bel7404 细胞中诱导 MiR-218 上调[1]。 Cell Proliferation Assay[1] Cell Line: HepG2, Bel7404 cells Concentration: 0, 1.25, 2.5, 5, 10 µg/mL Incubation Time: 0, 24, 48, 72 h Result: Inhibited cell proliferation of HepG2 and Bel7404 in a time- and dose-dependent manner. Apoptosis Analysis[1] Cell Line: HepG2 cells Concentration: 5 μg/ml Incubation Time: 72 h Result: Induced cell apoptosis. Western Blot Analysis[1] Cell Line: HepG2, Bel7404 cells Concentration: Incubation Time: Result: Suppressed Bmi-1 expressio and increased the expression of P14, P16 protein levels.
References	[1]. Fu WM, et al. MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells. Apoptosis. 2015 Jan;20(1):75-82.

Density	1.6±0.1 g/cm3
Boiling Point	509.2±50.0 °C at 760 mmHg
Molecular Formula	C₁₃H₈O₅
Molecular Weight	244.20
Flash Point	204.8±23.6 °C
Exact Mass	244.037170
PSA	90.90000
LogP	1.50
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.758

Hazard Codes	Xi
HS Code	2932999099

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

9H-Xanthen-9-one, 1,6,7-trihydroxy-

1,6,7-Trihydroxy-xanthon

1,6,7-Trihydroxy-xanthen-9-on

1,6,7-trihydroxy-xanthen-9-one

W2665

1,6,7-Trihydroxy-9H-xanthen-9-one

1,6,7-Trihydroxyxanthone

BioBioPha
China
Product Name: 1,6,7-Trihydroxy-9H-xanthen-9-one
Price: ￥3500.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

DC Chemicals Limited
China
Product Name: 1,6,7-Trihydroxyxanthone
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,6,7-Trihydroxyxanthone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥5590/5mg

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