D-Luciferin

Modify Date: 2026-07-01 18:51:52

D-Luciferin Structure
D-Luciferin structure
 Common Name D-Luciferin
CAS Number 2591-17-5 Molecular Weight 280.323
Density 1.8±0.1 g/cm3 Boiling Point 587.6±60.0 °C at 760 mmHg
Molecular Formula C11H8N2O3S2 Melting Point 200-204ºC
MSDS Chinese USA Flash Point 309.2±32.9 °C

 Use of D-Luciferin


D-luciferin is the natural substrate of luciferases that catalyze the production of light in bioluminescent insects.

 Names

Name Photinus luciferin
Synonym More Synonyms

 D-Luciferin Biological Activity

Description D-luciferin is the natural substrate of luciferases that catalyze the production of light in bioluminescent insects.
Related Catalog
In Vitro D-luciferin is the natural substrate of the enzyme luciferase (Luc), that catalyzes the production of the typical yellowgreen light of fireflies.The present review covers the synthesis of D-luciferin and derivatives or analogues that are substrates or inhibitors of the luciferase from the American firefly Photinus pyralis, the enzyme more frequently used in techniques of in vitro and optical imaging[1].
In Vivo Bioluminescence imaging (BLI) using the firefly luciferase (Fluc) as a reporter gene and D-luciferin as a substrate is currently the most widely employed technique. The total signal intensity is plotted against the time after D-luciferin injection to generate a time-intensity curve. In addition to the peak signal, the signals at fixed time points (5, 10, 15, and 20 min) after D-luciferin injection are determined as alternatives to the peak signal. The signal in a given time-intensity curve is normalized for the peak signal in the curve to represent the pattern of temporal changes after D-luciferin injection[2].
Animal Admin Mice[2] In vivo BLI is performed using a cooled charge-coupled device camera system (IVIS Imaging System 100) 3, 5, 7, 10, 12, 14, 19, 21, 24, and 28 days after the inoculation of HCT116-Luc cells. Mice are injected with 75 mg/kg D-luciferin in 100 μL of phosphate-buffered saline subcutaneously near the scapula and were placed in the light-tight chamber of the imaging system under isoflurane anesthesia. Beginning 5 min after injection, dorsal luminescent images with an exposure time of 1 s are acquired sequentially at a rate of one image per min until 20 min after D-luciferin injection. Data acquisition is continued until 40 min postinjection on days 3 or 5 and until 25 min on day 7, because of the prolonged time course of light emission. Binning is 4 and the field of view is 15 cm.
References

[1]. Giuseppe Meroni, et al. D-Luciferin, derivatives and analogues: synthesis and in vitro/in vivo luciferase-catalyzed bioluminescent activity. ARKIVOC 2009 (i) 265-288.

[2]. Inoue Y, et al. Timing of imaging after d-luciferin injection affects the longitudinal assessment of tumor growthusing in vivo bioluminescence imaging. Int J Biomed Imaging. 2010;2010:471408.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 587.6±60.0 °C at 760 mmHg
Melting Point 200-204ºC
Molecular Formula C11H8N2O3S2
Molecular Weight 280.323
Flash Point 309.2±32.9 °C
Exact Mass 279.997620
PSA 136.32000
LogP 0.87
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.865
InChIKey BJGNCJDXODQBOB-SSDOTTSWSA-N
SMILES O=C(O)C1CSC(c2nc3ccc(O)cc3s2)=N1
Storage condition -20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26-36/37/39
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2934999090

 Synthetic Route

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles350

More Articles
PSMA-specific CAR-engineered T cells eradicate disseminated prostate cancer in preclinical models.

PLoS ONE 9(10) , e109427, (2014)

Immunology-based interventions have been proposed as a promising curative chance to effectively attack postoperative minimal residual disease and distant metastatic localizations of prostate tumors. W...

Minimizing the non-specific binding of nanoparticles to the brain enables active targeting of Fn14-positive glioblastoma cells.

Biomaterials 42 , 42-51, (2014)

A major limitation in the treatment of glioblastoma (GBM), the most common and deadly primary brain cancer, is delivery of therapeutics to invading tumor cells outside of the area that is safe for sur...

Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis.

Oncotarget 6 , 15077-94, (2015)

The most abundant populations of non-neoplastic cells in the glioblastoma (GBM) microenvironment are resident microglia, macrophages and infiltrating monocytes from the blood circulation. The mechanis...

 D-LuciferinBioassay

View more

Name: Inhibition of NUAK1 (unknown origin) assessed as remaining activity at 100 uM by radi...
Source: ChEMBL
Target: NUAK family SNF1-like kinase 1
External Id: CHEMBL3427814
Name: Inhibition of MINK1 (unknown origin) assessed as remaining activity at 100 uM by radi...
Source: ChEMBL
Target: Misshapen-like kinase 1
External Id: CHEMBL3427815
Name: Inhibition of N-terminal His-tagged CDK2-cyclin A (unknown origin) assessed as remain...
Source: ChEMBL
Target: Cyclin-A2
External Id: CHEMBL3427812
Name: Inhibition of GSK-3beta (unknown origin) assessed as remaining activity at 100 uM by ...
Source: ChEMBL
Target: Glycogen synthase kinase-3 beta
External Id: CHEMBL3427813
Name: Inhibition of BRSK2 (unknown origin) assessed as remaining activity at 100 uM by radi...
Source: ChEMBL
Target: Serine/threonine-protein kinase BRSK2
External Id: CHEMBL3427818
Name: Inhibition of GCK (unknown origin) assessed as remaining activity at 100 uM by radioa...
Source: ChEMBL
Target: Mitogen-activated protein kinase kinase kinase kinase 2
External Id: CHEMBL3427819
Name: Inhibition of RSK2 (unknown origin) assessed as remaining activity at 100 uM by radio...
Source: ChEMBL
Target: Ribosomal protein S6 kinase alpha-3
External Id: CHEMBL3427816
Name: Inhibition of CAMK1 (unknown origin) assessed as remaining activity at 100 uM by radi...
Source: ChEMBL
Target: Calcium/calmodulin-dependent protein kinase type 1
External Id: CHEMBL3427817
Name: Inhibition of MLK3 (unknown origin) assessed as remaining activity at 100 uM by radio...
Source: ChEMBL
Target: Mitogen-activated protein kinase kinase kinase 11
External Id: CHEMBL3427822
Name: Inhibition of PIM2 (unknown origin) assessed as remaining activity at 100 uM by radio...
Source: ChEMBL
Target: Serine/threonine-protein kinase pim-2
External Id: CHEMBL3427823
Total 118, Current Page 1 of 12
1
2
3
4
5

 Synonyms

D-Leciferin
nbsp
D-LUCIFERIN FIREFLY
BEETLE LUCIFERIN
(S)-4,5-Dihydro-2-(6-hydroxy-1,3-benzothiazol-2-yl)thiazole-4-carboxylic acid
D-Luciferin
(4S)-2-(6-Hydroxy-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid
D-(-)-Luciferin
LUCIFERIN
EINECS 219-981-3
(S)-2-(6-Hydroxy-2-benzothiazolyl)-2-thiazoline-4-carboxylic Acid
firefly liciferin
Firefly luciferin
MFCD00042929
(S)-4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylicacid
(S)-2-(6-Hydroxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid
AURORA KA-6717
firefly luciferin IV
(S)-luciferin
LUCIFERIN,D
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

D-Luciferin suppliers

Price: $86/10mM*1mLinDMSO

Reference only. check more D-Luciferin price

Related Compounds: More...
3-chloro-5-[(5-chloro-1H-indazol-4-yl)oxy]benzonitrile
1034474-32-2
N-cyclopentyl-2-(3-fluorobenzyl)-4-(3-methylbutyl)-1,5-dioxo-1,2,4,5-tetrahydro[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
1242918-86-0
N-cyclopentyl-4-isopentyl-2-(4-methylbenzyl)-1,5-dioxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
1242866-31-4
(16alpha,20S,22S,23S)-16,23:22,25-diepoxy-2,22,23-trihydroxycucurbita-1,5-diene-3,11-dione 2-O-beta-D-glucopyranoside
1345690-54-1
4-benzyl-N-isobutyl-1,5-dioxo-2-(4-vinylbenzyl)-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
1242872-75-8
2-(3-fluorobenzyl)-N,4-diisopropyl-1,5-dioxo-1,2,4,5-tetrahydro[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
1242982-44-0
N-cyclopentyl-2-(4-fluorobenzyl)-4-(3-methylbutyl)-1,5-dioxo-1,2,4,5-tetrahydro[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
1243049-07-1
N-isobutyl-4-(3-methylbutyl)-2-[2-(4-methylphenyl)-2-oxoethyl]-1,5-dioxo-1,2,4,5-tetrahydro[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
1223968-97-5
4-benzyl-N-isobutyl-2-(3-methoxybenzyl)-1,5-dioxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
1242991-52-1
2-(cyanomethyl)-N-cyclopentyl-4-(4-methylbenzyl)-1,5-dioxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinazoline-8-carboxamide
1224013-57-3
Chemsrc provides D-Luciferin(CAS#:2591-17-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of D-Luciferin are included as well.>> amp version: D-Luciferin

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2026 ChemSrc All Rights Reserved