Octaethylene glycol monomethyl ether

Modify Date: 2024-01-03 17:18:30

Octaethylene glycol monomethyl ether Structure
Octaethylene glycol monomethyl ether structure
Common Name Octaethylene glycol monomethyl ether
CAS Number 25990-96-9 Molecular Weight 384.462
Density 1.1±0.1 g/cm3 Boiling Point 454.0±40.0 °C at 760 mmHg
Molecular Formula C17H36O9 Melting Point N/A
MSDS N/A Flash Point 228.4±27.3 °C

 Use of Octaethylene glycol monomethyl ether


Octaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Synonym More Synonyms

 Octaethylene glycol monomethyl ether Biological Activity

Description Octaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 454.0±40.0 °C at 760 mmHg
Molecular Formula C17H36O9
Molecular Weight 384.462
Flash Point 228.4±27.3 °C
Exact Mass 384.235931
PSA 94.07000
LogP -3.30
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.451
Storage condition 2-8°C

 Safety Information

HS Code 2909499000

 Customs

HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

 Synonyms

2,5,8,11,14,17,20,23-Octaoxapentacosan-25-ol
3,6,9,12,15,18,21,24-Octaoxapentacosan-1-ol
polyethylene(n ca. 8)glycol monomethyl ether
23-methoxy-3,6,9,12,15,18,21-heptaoxa-tricosan-1-ol
Octaethylene Glycol MonoMethyl Ether
O-methyl-octaethylene glycol
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