Nonaethylene glycol monomethyl ether

Modify Date: 2024-01-02 10:49:24

Nonaethylene glycol monomethyl ether Structure
Nonaethylene glycol monomethyl ether structure
Common Name Nonaethylene glycol monomethyl ether
CAS Number 6048-68-6 Molecular Weight 428.515
Density 1.1±0.1 g/cm3 Boiling Point 490.1±40.0 °C at 760 mmHg
Molecular Formula C19H40O10 Melting Point 14ºC
MSDS N/A Flash Point 250.2±27.3 °C

 Use of Nonaethylene glycol monomethyl ether


Nonaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Synonym More Synonyms

 Nonaethylene glycol monomethyl ether Biological Activity

Description Nonaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 490.1±40.0 °C at 760 mmHg
Melting Point 14ºC
Molecular Formula C19H40O10
Molecular Weight 428.515
Flash Point 250.2±27.3 °C
Exact Mass 428.262146
PSA 103.30000
LogP -3.66
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.453
Storage condition 2-8°C

 Safety Information

HS Code 2909440000

 Synthetic Route

~99%

Nonaethylene glycol monomethyl ether Structure

Nonaethylene gl...

CAS#:6048-68-6

Literature: SMITHKLINE BEECHAM CORPORATION Patent: WO2005/102976 A1, 2005 ; Location in patent: Page/Page column 10-11 ;

~49%

Nonaethylene glycol monomethyl ether Structure

Nonaethylene gl...

CAS#:6048-68-6

Literature: UNIVERSITA DEGLI STUDI DI SIENA Patent: WO2008/37604 A1, 2008 ; Location in patent: Page/Page column 19 ;

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Nonaethylene glycol monomethyl ether Structure

Nonaethylene gl...

CAS#:6048-68-6

Literature: US2798873 , ;

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Nonaethylene glycol monomethyl ether Structure

Nonaethylene gl...

CAS#:6048-68-6

Literature: US2858315 , ;

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Nonaethylene glycol monomethyl ether Structure

Nonaethylene gl...

CAS#:6048-68-6

Literature: US2798873 , ;

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Nonaethylene glycol monomethyl ether Structure

Nonaethylene gl...

CAS#:6048-68-6

Literature: US2858315 , ;

 Customs

HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

 Synonyms

Nonaethylene Glycol Monomethyl Ether
O-methyl-nonaethyleneglycol
O-Methyl-nonaaethylenglykol
3,6,9,12,15,18,21,24,27-Nonaoxaoctacosan-1-ol
3,6,9,12,15,18,21,24,27-Nonaoxaoctacosanol
2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-ol
O-methyl-nonaaethylene glycol
Nonaethylene glycol monomethyl ether
MPEG9-OH
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