Tetraethylene glycol monomethyl ether

Modify Date: 2026-06-30 22:49:06

Tetraethylene glycol monomethyl ether Structure
Tetraethylene glycol monomethyl ether structure
 Common Name Tetraethylene glycol monomethyl ether
CAS Number 23783-42-8 Molecular Weight 208.252
Density 1.0±0.1 g/cm3 Boiling Point 285.4±25.0 °C at 760 mmHg
Molecular Formula C9H20O5 Melting Point N/A
MSDS Chinese USA Flash Point 126.4±23.2 °C

 Use of Tetraethylene glycol monomethyl ether


Tetraethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol
Synonym More Synonyms

 Tetraethylene glycol monomethyl ether Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Tetraethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.0±0.1 g/cm3
Boiling Point 285.4±25.0 °C at 760 mmHg
Molecular Formula C9H20O5
Molecular Weight 208.252
Flash Point 126.4±23.2 °C
Exact Mass 208.131073
PSA 57.15000
LogP -1.87
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.436
InChIKey ZNYRFEPBTVGZDN-UHFFFAOYSA-N
SMILES COCCOCCOCCOCCO

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
Hazard Codes Xi
Safety Phrases S24/25
RIDADR NONH for all modes of transport
HS Code 2909499000

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

 Articles1

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Towards controlled polymer brushes via a self-assembly-assisted-grafting-to approach.

Nat. Commun. 7 , 11119, (2016)

Precise synthesis of polymer brushes to modify the surface of nanoparticles and nanodevices for targeted applications has been one of the major focuses in the community for decades. Here we report a s...

 Tetraethylene glycol monomethyl etherBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Name: qHTS assay to identify small molecule antagonists of the peroxisome proliferator-acti...
Source: 824
Target: N/A
External Id: PPARGV841
Name: qHTS assay to identify small molecule agonists of the TGF-beta/Smad signaling pathway...
Source: 824
Target: N/A
External Id: TGF788
Name: qHTS assay to identify small molecule antagonists of the TGF-beta/Smad signaling path...
Source: 824
Target: N/A
External Id: TGF602
Name: qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell fr...
Source: 824
Target: N/A
External Id: SPEC167MG
Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
Name: qHTS assay to identify small molecule agonists of the peroxisome proliferator-activat...
Source: 824
Target: N/A
External Id: PPARDV813
Name: qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cell free...
Source: 824
Target: N/A
External Id: SPEC167MR
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958
Name: qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells
Source: 824
Target: N/A
External Id: SPEC167CG
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Tetraethyleneglycol monomethyl ether
MFCD00041756
2,5,8,11-Tetraoxatridecan-13-ol
3,6,9,12-tetraoxatridecan-1-ol
Methyl Tetraglycol
3,6,9,12-tetraoxatridecanol
DSSTox_CID_7829
Tetraethylene Glycol MonoMethyl Ether
EINECS 245-883-5
AmbotzPEG2155
methyltetraglycol

 Tetraethylene glycol monomethyl ether | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the English name of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol?
A: The English name of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol is 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol.
Q: What is the CAS number of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol?
A: CAS number of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol is 23783-42-8.
Q: What are the downstream products of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol?
A: Related downstream products(CAS) of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol: 104779-02-4;16024-66-1;16024-60-5;1191-91-9;78463-25-9;85030-56-4;87117-60-0;848589-21-9;89769-11-9;96220-75-6.
Q: What is the boiling point of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol?
A: Boiling point of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol is 285.4±25.0 °C at 760 mmHg.
Q: What are the upstream materials of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol?
A: Related upstream materials(CAS) of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol: 87117-61-1;112-60-7;74-88-4;77-78-1;74654-05-0;107-21-1;112-35-6;86259-87-2;727986-31-4;73159-12-3.
Q: What is the molecular weight of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol?
A: Molecular weight of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol is 208.252.
Q: What is the SMILES notation of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol?
A: SMILES notation of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol is COCCOCCOCCOCCO.
Q: What is the molecular formula of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol?
A: Molecular formula of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol is C9H20O5.
Q: What is the InChIKey of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol?
A: InChIKey of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol is ZNYRFEPBTVGZDN-UHFFFAOYSA-N.
Q: What is the polar surface area (PSA) of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol?
A: Polar surface area (PSA) of 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol is 57.15000.

 Tetraethylene glycol monomethyl etherfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
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