Etamsylate

Modify Date: 2024-01-01 22:19:48

Etamsylate Structure
Etamsylate structure
 Common Name Etamsylate
CAS Number 2624-44-4 Molecular Weight 263.311
Density N/A Boiling Point 496.4ºC at 760 mmHg
Molecular Formula C10H17NO5S Melting Point 127-131ºC
MSDS N/A Flash Point 254ºC

 Use of Etamsylate


Ethamsylate is a haemostatic drug, also inhibits biosynthesis and action of those prostaglandins.

 Names

Name 2,5-Dihydroxybenzenesulfonic acid N-ethylethanamine (1:1)
Synonym More Synonyms

 Etamsylate Biological Activity

Description Ethamsylate is a haemostatic drug, also inhibits biosynthesis and action of those prostaglandins.
Related Catalog

 Chemical & Physical Properties

Boiling Point 496.4ºC at 760 mmHg
Melting Point 127-131ºC
Molecular Formula C10H17NO5S
Molecular Weight 263.311
Flash Point 254ºC
Exact Mass 263.082733
PSA 115.24000
LogP 2.43200
Vapour Pressure 1.13E-10mmHg at 25°C
Storage condition 2~8 ℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DB6145000
CHEMICAL NAME :
Benzenesulfonic acid, 2,5-dihydroxy-, compd. with diethylamine
CAS REGISTRY NUMBER :
2624-44-4
LAST UPDATED :
199806
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C6-H6-O5-S.C4-H11-N
MOLECULAR WEIGHT :
263.34
WISWESSER LINE NOTATION :
WSQR BQ EQ &2M2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
29750 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - excitement
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6040 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
760 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
3500 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - excitement

MUTATION DATA

TYPE OF TEST :
Sex chromosome loss and nondisjunction
TEST SYSTEM :
Mold - Aspergillus nidulans
DOSE/DURATION :
1 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974

 Safety Information

Hazard Codes Xi
HS Code 2921199090

 Customs

HS Code 2922299090
Summary 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles25

More Articles
Application and equivalence assessment for determining ethamsylate by using potassium ferricyanide as spectroscopic probe reagent.

Anal. Sci. 26(11) , 1163-7, (2010)

In this paper, a novel method has been established to determine ethamsylate using potassium ferricyanide as a spectroscopic probe reagent. It has been demonstrated that Fe(III) is reduced to Fe(II) by...

Simultaneous determination of aminomethylbenzoic acid, cefminox sodium and etamsylate in human urine by capillary electrophoresis.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 878(21) , 1899-903, (2010)

A sensitive and selective capillary electrophoresis method is developed, for the first time, for effective separation and simultaneous determination of aminomethylbezoic acid (PAMBA), cefminox sodium ...

A novel visible spectrophotometric method for the determination of ethamsylate in pharmaceutical preparations and biological samples.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 75(3) , 1013-7, (2010)

A highly sensitive visible spectrophotometric method has been developed to determine ethamsylate in this paper, which is based on using Cu(II) as spectroscopic probe reagent. The study indicates that ...

 Synonyms

Diethylamine 2,5-Dihydroxybenzenesulfonate
1-Hydroxy-4-oxo-2,5-cyclohexadiene-1-sulfonic Acid Compd with Diethylamine
2,5-Dihydroxybenzenesulfonic acid - N-ethylethanamine (1:1)
MFCD00867499
Etamsylate
EINECS 220-090-7
Ethamsylate
2,5-Dihydroxybenzenesulfonic Acid Compd with N-Ethylethanamine
Benzenesulfonic acid, 2,5-dihydroxy-, compd. with N-ethylethanamine (1:1)
Benzenesulfonic acid,2,5-dihydroxy-,compd. with N-ethylethanamine
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134104-43-1
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131615-57-1
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930439-75-1
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1018584-77-4
tert-Butyl-DL-alanine
1375289-11-4
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