Adenosine,2'-chloro-2'-deoxy-

Modify Date: 2024-01-10 17:55:02

Adenosine,2'-chloro-2'-deoxy- Structure
Adenosine,2'-chloro-2'-deoxy- structure
 Common Name Adenosine,2'-chloro-2'-deoxy-
CAS Number 2627-62-5 Molecular Weight 285.69
Density 2.03g/cm3 Boiling Point 678.2ºC at 760mmHg
Molecular Formula C10H12ClN5O3 Melting Point N/A
MSDS N/A Flash Point 364ºC

 Use of Adenosine,2'-chloro-2'-deoxy-


2’-Chloro-2’-deoxyadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-chloro-2-(hydroxymethyl)oxolan-3-ol
Synonym More Synonyms

 Adenosine,2'-chloro-2'-deoxy- Biological Activity

Description 2’-Chloro-2’-deoxyadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 2.03g/cm3
Boiling Point 678.2ºC at 760mmHg
Molecular Formula C10H12ClN5O3
Molecular Weight 285.69
Flash Point 364ºC
Exact Mass 285.06300
PSA 119.31000
Vapour Pressure 2.54E-19mmHg at 25°C
Index of Refraction 1.87

 Synthetic Route

3',5'-O-(1,1,3,3-tetraisopropyldisilox-1,3-diyl)-9-(2-chloro-2-deoxy-β-D-arabinofuranosyl)adenine structure

3',5'-O-(1,1,3,...

CAS#:85335-82-6

~82%

Adenosine,2'-chloro-2'-deoxy- Structure

Adenosine,2'-ch...

CAS#:2627-62-5

Literature: Fukukawa; Uedao; Hirano Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 5 p. 1582 - 1592
3,5-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)adenosine structure

3,5-O-(1,1,3,3-...

CAS#:69304-45-6

~%

Adenosine,2'-chloro-2'-deoxy- Structure

Adenosine,2'-ch...

CAS#:2627-62-5

Literature: Fukukawa; Uedao; Hirano Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 5 p. 1582 - 1592
3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-O-(trifluoromethanesulfonyl)adenosine structure

3',5'-O-(1,1,3,...

CAS#:88121-20-4

~%

Adenosine,2'-chloro-2'-deoxy- Structure

Adenosine,2'-ch...

CAS#:2627-62-5

Literature: Fukukawa; Uedao; Hirano Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 5 p. 1582 - 1592

 Synonyms

2'-deoxy-2'-chloroadenosine
2'-Chlor-2'-deoxy-adenosin
Adenosine,2'-chloro-2'-deoxy
2'-chloro-2'-deoxy-adenosine
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