CDK5-IN-3

Modify Date: 2024-01-14 18:38:55

CDK5-IN-3 Structure
CDK5-IN-3 structure
Common Name CDK5-IN-3
CAS Number 2639542-32-6 Molecular Weight 362.47
Density N/A Boiling Point N/A
Molecular Formula C22H26N4O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CDK5-IN-3


CDK5-IN-3 (compound 11) is a potent and selective CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD)[1].

 Names

Name CDK5-IN-3

 CDK5-IN-3 Biological Activity

Description CDK5-IN-3 (compound 11) is a potent and selective CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD)[1].
Related Catalog
Target

Cdk5/p25:0.6 nM (IC50)

CDK2/CycA:18 nM (IC50)

References

[1]. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022 Feb 24;65(4):3575-3596.

 Chemical & Physical Properties

Molecular Formula C22H26N4O
Molecular Weight 362.47
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