Xanthine oxidase-IN-4

Modify Date: 2024-01-03 17:18:38

Xanthine oxidase-IN-4 structure	Common Name	Xanthine oxidase-IN-4
	CAS Number	2642137-96-8	Molecular Weight	295.30
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₃N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Xanthine oxidase-IN-4

Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent xanthine oxidase (XO) inhibitor, with an IC50 of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research[1].

Name	Xanthine oxidase-IN-4

Description	Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent xanthine oxidase (XO) inhibitor, with an IC50 of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase
Target	IC50: 0.039 μM (xanthine oxidase)[1]
In Vitro	Xanthine oxidase-IN-4 (compound 19a) (1 nM-10 μM, 15 min) exhibits a strong XO inhibitory potency, with an IC50 of 0.039 μM, and Ki of 0.0037 μM[1].
In Vivo	Xanthine oxidase-IN-4 (compound 19a) (SD rats, 10 mg/kg, Intragastrically, once) significantly reduces the serum concentration of uric acid[1]. Animal Model: Sprague-Dawley rats (Six weeks, male, 180-200g, six groups)[1] Dosage: 10 mg/kg Administration: Intragastrically, once Result: Significantly reduced the serum concentration of uric acid, with AUC (uric acid, 1-5 h) of 44.3%.
References	[1]. Zhao J, et al. Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors. Eur J Med Chem. 2022;229:114086.

Molecular Formula	C₁₅H₁₃N₅O₂
Molecular Weight	295.30

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Xanthine oxidase-IN-4

Use of Xanthine oxidase-IN-4

Names

Xanthine oxidase-IN-4 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.