GRP78-IN-3

Modify Date: 2023-02-04 16:47:12

GRP78-IN-3 structure	Common Name	GRP78-IN-3
	CAS Number	2707510-30-1	Molecular Weight	342.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₈N₄O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GRP78-IN-3

GRP78-IN-3 is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 μM)[1].

Name	GRP78-IN-3

Description	GRP78-IN-3 is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 μM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Target	HSPA5:0.59 μM (IC50)
In Vitro	GRP78-IN-3 (compound 8) is a potent small-molecule-competitive inhibitor of Hsp70 substrate binding. GRP78-IN-3 (0.1-100 μM) shows more potent inhibition efffects in a spheroid tumor model (U251 glioblastoma cells and H520 lung cancer cells)[1].
References	[1]. Andrew J Ambrose, et al. Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78. J Med Chem. 2022 Dec 14.

Molecular Formula	C₁₇H₁₈N₄O₂S
Molecular Weight	342.42

GRP78-IN-3

Use of GRP78-IN-3

Names

GRP78-IN-3 Biological Activity

Chemical & Physical Properties