NOS-IN-3

Modify Date: 2024-01-16 20:03:56

NOS-IN-3 structure	Common Name	NOS-IN-3
	CAS Number	2761725-68-0	Molecular Weight	193.25
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀H₁₅N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NOS-IN-3

NOS-IN-3 (Compound 9a) is a potent, selective, imidamide derived NOS inhibitor with an IC50 against iNOS of 4.6 µM, without inhibiting eNOS. NOS-IN-3 has little toxicity and can be studied in the treatment of inducible isoform involved diseases, such as septic shock[1].

Name	NOS-IN-3

Description	NOS-IN-3 (Compound 9a) is a potent, selective, imidamide derived NOS inhibitor with an IC50 against iNOS of 4.6 µM, without inhibiting eNOS. NOS-IN-3 has little toxicity and can be studied in the treatment of inducible isoform involved diseases, such as septic shock[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology
Target	IC50: 4.6 µM (iNOS), > 1000 µM (nNOS)[1]
In Vitro	NOS-IN-3 (Compound 9a) shows high iNOS selectivity without eNOS inhibition activity [1]. NOS-IN-3 (0-100 µM, 30 min) has little toxicity[1]. Cell Viability Assay[1] Cell Line: HUVECs Concentration: 10, 20, 50, 100, 500 µM Incubation Time: 30 min Result: Had little toxicity, only at the concentration above 100 µM, the cell viability was significantly (approximately 20%) reduced.
References	[1]. Fabio Arias, et al. Bioactive imidamide-based compounds targeted against nitric oxide synthase. Bioorg Chem. 2022 Feb 2;120:105637.

Molecular Formula	C₁₀H₁₅N₃O
Molecular Weight	193.25

NOS-IN-3

Use of NOS-IN-3

Names

NOS-IN-3 Biological Activity

Chemical & Physical Properties