RLX-33
Modify Date: 2023-02-23 10:53:14
RLX-33 structure
|
Common Name | RLX-33 | ||
|---|---|---|---|---|
| CAS Number | 2784577-71-3 | Molecular Weight | 462.89 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H19ClN4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RLX-33RLX-33 is a potent, selective and blood-brain barrier (BBB) penetrant relaxin family peptide 3 (RXFP3) antagonist, also blocks relaxin-3-induced ERK1/2 phosphorylation, with IC50 values of 2.36 μM for RXFP3, 7.82 and 13.86 μM for ERK1 and ERK2 phosphorylation, respectively. RLX-33 can block the stimulation of food intake induced by the RXFP3-selective agonist R3/I5 in rats. RLX-33 can be used for the research of metabolic syndrome[1]. |
| Name | RLX-33 |
|---|
| Description | RLX-33 is a potent, selective and blood-brain barrier (BBB) penetrant relaxin family peptide 3 (RXFP3) antagonist, also blocks relaxin-3-induced ERK1/2 phosphorylation, with IC50 values of 2.36 μM for RXFP3, 7.82 and 13.86 μM for ERK1 and ERK2 phosphorylation, respectively. RLX-33 can block the stimulation of food intake induced by the RXFP3-selective agonist R3/I5 in rats. RLX-33 can be used for the research of metabolic syndrome[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 2.36 μM (RXFP3), 7.82 μM (ERK1 phosphorylation), 13.86 μM (ERK2 phosphorylation)[1] |
| In Vivo | RLX-33 (10 mg/kg; IP, single dosage) attenuates the RXFP3-selective agonist R3/I5-induced increase in feeding in male Wistar rats[1]. RLX-33 (10 mg/kg; IP, single dosage) exhibits a good brain penetration and highly protein-bound in rats plasma[1]. Pharmacokinetic Parameters of RLX-33 in male Wistar rats (IP, 10 mg/kg)[1]. plasma brain Cmax (ng/mL) 1401 1552 tmax (h) 0.5 2.0 t1/2 (h) 1.9 4.9 AUCinf (ng/mL·h) 5352 12519 CL_F (mL/min/kg) 43.8 Animal Model: Male Wistar rats (intracerebroventricular administration of R3/I5 stimulated food intake[1] Dosage: 10 mg/kg Administration: IP, single dosage Result: Attenuated the R3/I5-induced increase in food intake. Animal Model: Male Wistar rats[1] Dosage: 10 mg/kg Administration: IP, single dosage (Pharmacokinetic Analysis) Result: Exhibited a good brain penetration and highly protein-bound, with protein binding of 99.8% in rat plasma. |
| References |
| Molecular Formula | C24H19ClN4O4 |
|---|---|
| Molecular Weight | 462.89 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: RLX-33
- Price: Negotiable
- Purity: 99.82%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: RLX-33
- Price: ￥650.0/100mg ￥1100.0/250mg ￥2200.0/1g
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
Get all suppliers and price by the below link: