HOOBT

Modify Date: 2024-01-02 11:30:29

HOOBT Structure
HOOBT structure
 Common Name HOOBT
CAS Number 28230-32-2 Molecular Weight 163.133
Density 1.6±0.1 g/cm3 Boiling Point 348.7±25.0 °C at 760 mmHg
Molecular Formula C7H5N3O2 Melting Point 184-189°C
MSDS Chinese Flash Point 164.7±23.2 °C
Symbol GHS02 GHS07 GHS08
GHS02, GHS07, GHS08		 Signal Word Danger

 Use of HOOBT


HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer[1].

 Names

Name 3-hydroxy-1,2,3-benzotriazin-4-one
Synonym More Synonyms

 HOOBT Biological Activity

Description HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer[1].
Related Catalog
Target

STAT5

In Vitro HODHBt (100 μM; 24 h, and 48 h respectively) increases IL-15-mediated STAT phosphorylation in NK cells and enhances the cytotoxic profile of NK cells[1]. HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL) cytotoxicity of NK cells against HIV-infected cells (K562 cells)[1]. HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL, 6 h) cytotoxicity of NK cells against cancer cell lines (A2780 and U877; OCILy1 and OCILy10)[1]. HODHBt (100 μM; 7 d) results in enhanced memory response upon recall in generation of human CIML NK cells in vitro[1].

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 348.7±25.0 °C at 760 mmHg
Melting Point 184-189°C
Molecular Formula C7H5N3O2
Molecular Weight 163.133
Flash Point 164.7±23.2 °C
Exact Mass 163.038177
PSA 68.01000
LogP 0.43
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.739
Storage condition 2-8°C

 Safety Information

Symbol GHS02 GHS07 GHS08
GHS02, GHS07, GHS08
Signal Word Danger
Hazard Statements H226-H312 + H332-H315-H319-H335-H360D
Precautionary Statements P201-P261-P280-P305 + P351 + P338-P308 + P313
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S53-S26-S35-S36/37-S45-S37/39
RIDADR UN 3379 3/PG 1
WGK Germany 3
Hazard Class 3.0
HS Code 2933699090

 Synthetic Route

Benzamide,2-amino-N-hydroxy- structure

Benzamide,2-ami...

CAS#:5623-04-1

~77%

HOOBT Structure

HOOBT

CAS#:28230-32-2

Literature: FRUTAROM LTD. Patent: WO2005/7634 A1, 2005 ; Location in patent: Page 39 ;
2-oxo-1H-3,2λ4,1-benzoxathiazin-4-one structure

2-oxo-1H-3,2λ4,...

CAS#:60941-84-6

~%

HOOBT Structure

HOOBT

CAS#:28230-32-2

Literature: Jakobsen, Mogens Havsteen; Buchardt, Ole; Holm, Arne; Meldal, Morten Synthesis, 1990 , # 11 p. 1008 - 1010
Methyl 2-aminobenzoate structure

Methyl 2-aminob...

CAS#:134-20-3

~%

HOOBT Structure

HOOBT

CAS#:28230-32-2

Literature: Vaughan, Keith; Wilman, Derry E. V.; Wheelhouse, Richard T.; Stevens, Malcolm F. G. Magnetic Resonance in Chemistry, 2002 , vol. 40, # 4 p. 300 - 302

 Customs

HS Code 2933699090
Summary 2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%

 Synonyms

HOOBT
EINECS 248-916-1
3-hydroxybenzo[d]1,2,3-triazin-4-one
3-hydroxy-3H-benzo[d][1,2,3]triazin-4-one
1,2,3-Benzotriazin-4(3H)-one, 3-hydroxy-
DHBT
oxohydroxybenzotriazole
4-oxo-3,4-dihydro-3-hydroxy-1,2,3-benzotriazine
3-Hydroxy-1,2,3-benzotriazin-4(3H)-one
3-Hydroxy-4-ketobenzotriazine
3-Hydroxy-1,2,3-ben zotriazin-4(3H)-one
3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine
1,2,3-Benzotriazin-4(3H)-one,3-hydroxy
MFCD00042803
3,4-dihydro-3-hydroxy-4-keto-1,2,3-benzotriazine
3-Hydroxy-3,4-dihydro-4-oxo-1,2,3-benzotriazine
Top Suppliers:I want be here

Get all suppliers and price by the below link:

HOOBT suppliers

HOOBT price

Related Compounds: More...
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1018584-77-4
tert-Butyl-DL-alanine
1375289-11-4
Methyl amino(1-naphthyl)acetate hydrochloride
13227-00-4
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
849349-65-1
Chemsrc provides HOOBT(CAS#:28230-32-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of HOOBT are included as well.>> amp version: HOOBT

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved