10-Formyl-7,8-dihydrofolic acid

Modify Date: 2025-08-25 11:54:26

10-Formyl-7,8-dihydrofolic acid Structure
10-Formyl-7,8-dihydrofolic acid structure
 Common Name 10-Formyl-7,8-dihydrofolic acid
CAS Number 28459-40-7 Molecular Weight 471.42300
Density 1.67g/cm3 Boiling Point N/A
Molecular Formula C20H21N7O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 10-Formyl-7,8-dihydrofolic acid


10-Formyl-7,8-dihydrofolic acid is a substrate for mammalian aminoimidazolecarboxamide ribotide transformylase (EC 2.1.2.3). 10-Formyl-7,8-dihydrofolic acid also is a metabolite of 10-HCO-H4folate[1][2].

 Names

Name 10-formyldihydrofolic acid
Synonym More Synonyms

 10-Formyl-7,8-dihydrofolic acid Biological Activity

Description 10-Formyl-7,8-dihydrofolic acid is a substrate for mammalian aminoimidazolecarboxamide ribotide transformylase (EC 2.1.2.3). 10-Formyl-7,8-dihydrofolic acid also is a metabolite of 10-HCO-H4folate[1][2].
Related Catalog
References

[1]. Baggott JE, et al. Iron compounds catalyze the oxidation of 10-formyl-5,6,7,8 tetrahydrofolic acid to 10-formyl-7,8 dihydrofolic acid. J Inorg Biochem. 1998 Sep;71(3-4):181-7.  

[2]. Baggott JE, et al. Metabolism of 10-formyldihydrofolate in humans. Biomed Pharmacother. 2001 Oct;55(8):454-7.  

 Chemical & Physical Properties

Density 1.67g/cm3
Molecular Formula C20H21N7O7
Molecular Weight 471.42300
Exact Mass 471.15000
PSA 221.16000
LogP 0.50370

 Synthetic Route

L-5,6,7,8-Tetrahydrofolic acid structure

L-5,6,7,8-Tetra...

CAS#:135-16-0

L-Glutamic acid,N-(iminomethyl)- structure

L-Glutamic acid...

CAS#:816-90-0

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10-Formyl-7,8-dihydrofolic acid Structure

10-Formyl-7,8-d...

CAS#:28459-40-7

Literature: Miller et al. Archives of Biochemistry, 1956 , vol. 63, p. 263

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

10-Formyl-7,8-dihydro Folic Acid
(2S)-2-[[4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid
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