Guanfacine-13C,15N3

Modify Date: 2024-01-13 17:42:11

Guanfacine-13C,15N3 Structure
Guanfacine-13C,15N3 structure
Common Name Guanfacine-13C,15N3
CAS Number 1189924-28-4 Molecular Weight 250.06600
Density N/A Boiling Point N/A
Molecular Formula C9H9Cl2N3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Guanfacine-13C,15N3


Guanfacine-13C,15N3 is the 13C and 15N labeled Guanfacine[1]. Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD)[2][3][4].

 Names

Name N-[bis(azanyl)methylidene]-2-(2,6-dichlorophenyl)acetamide
Synonym More Synonyms

 Guanfacine-13C,15N3 Biological Activity

Description Guanfacine-13C,15N3 is the 13C and 15N labeled Guanfacine[1]. Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD)[2][3][4].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Amy F T Arnsten, et al. Guanfacine for the treatment of cognitive disorders: a century of discoveries at Yale. Yale J Biol Med. 2012 Mar;85(1):45-58. Epub 2012 Mar 29.  

[3]. P. A. Van Zwieten, et al. The pharmacology of centrally acting antihypertensive drugs. Br J Clin Pharmacol. 1983 15(Suppl 4): 455S–462S.

[4]. Min Wang, et al. Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell. 2007 Apr 20129(2):397-410.  

 Chemical & Physical Properties

Molecular Formula C9H9Cl2N3O
Molecular Weight 250.06600
Exact Mass 249.00700
PSA 82.46000
LogP 3.18590

 Synonyms

Guarfacine-13C,15N3
Guanfacine-13C,15N3
Guanfacine0-13C,15N3
Guanfascine-13C,15N3