Nicotredole
Modify Date: 2024-01-09 11:57:01
Nicotredole structure
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Common Name | Nicotredole | ||
|---|---|---|---|---|
| CAS Number | 29876-14-0 | Molecular Weight | 265.310 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 588.4±35.0 °C at 760 mmHg | |
| Molecular Formula | C16H15N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 309.7±25.9 °C | |
Use of NicotredoleNicotredole (Tryptamide) is an orally active anti-inflammatory and analgesic agent. Nicotredole exhibits evident antiinflammatory effects of potency comparable with Phenylbutazone. Nicotredole has only weak ulcerogenic activity[1][2][3]. |
| Name | N-[2-(1H-indol-3-yl)ethyl]pyridine-3-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | Nicotredole (Tryptamide) is an orally active anti-inflammatory and analgesic agent. Nicotredole exhibits evident antiinflammatory effects of potency comparable with Phenylbutazone. Nicotredole has only weak ulcerogenic activity[1][2][3]. |
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| Related Catalog | |
| In Vitro | Nicotredole inhibits prostaglandin synthetase activity in vitro[1]. |
| In Vivo | Nicotredole produces antiinflammatory effects in carrageenin-induced rat paw oedema[1]. Nicotredole reverses pyrogen-induced hyperthermia in rats, elicits analgesic effects in rats, prolongs the time of hexobarbital sleep in rats and inhibits locomotor activity in rats and mice[1]. Nicotredole (i.p.) has LD50s of 1260 mg/kg and 1980 mg/kg for male rats and male mice, respectively[1]. Nicotredole (p.o.) has LD50s of 8.5 g/kg and 9.3 g/kg for male rats and male mice, respectively[1]. Nicotredole (25 mg/kg; p.o. or i.p.) undergoes fast absorption (t1/2=4.92-17.5 min) and elimination (t1/2=55.72-74.52 min), can reach Cmax (11-13 μg/cm3) after 30 min, and gives AUC values in the range of 21.40-27.30 (μg•h/cm3)[2]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 588.4±35.0 °C at 760 mmHg |
| Molecular Formula | C16H15N3O |
| Molecular Weight | 265.310 |
| Flash Point | 309.7±25.9 °C |
| Exact Mass | 265.121521 |
| PSA | 57.78000 |
| LogP | 1.94 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.669 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Hazard Codes | Xi |
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~%
Nicotredole CAS#:29876-14-0 |
| Literature: Journal of the American Chemical Society, , vol. 126, # 40 p. 12897 - 12906 |
|
~60%
Nicotredole CAS#:29876-14-0 |
| Literature: Rodriguez-Lugo, Rafael E.; Trincado, Monica; Gruetzmacher, Hansjoerg ChemCatChem, 2013 , vol. 5, # 5 p. 1079 - 1083 |
|
~81%
Nicotredole CAS#:29876-14-0 |
| Literature: Bodor; Farag; Polgar Journal of Pharmacy and Pharmacology, 2001 , vol. 53, # 6 p. 889 - 894 |
|
~62%
Nicotredole CAS#:29876-14-0 |
| Literature: Lo, Kenneth Kam-Wing; Tsang, Keith Hing-Kit; Hui, Wai-Ki; Zhu, Nianyong Chemical Communications, 2003 , # 21 p. 2704 - 2705 |
|
~%
Nicotredole CAS#:29876-14-0 |
| Literature: Canadian Journal of Research, Section B: Chemical Sciences, , vol. 24, p. 224,229 |
| nicotredole |
| 3-Pyridinecarboxamide, N-[2-(1H-indol-3-yl)ethyl]- |
| Tryptamide |
| N-Nicotinoyltryptamide |
| N-[2-(1H-Indol-3-yl)ethyl]nicotinamide |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Nicotredole
- Price: ￥238.0/50mg ￥698.0/250mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Nicotredole
- Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 3-Pyridinecarboxamide,N-[2-(1H-indol-3-yl)ethyl]-
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
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Price: ￥402/250mg
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