Eledoisin-Related Peptide TFA

Modify Date: 2024-01-05 22:49:52

Eledoisin-Related Peptide TFA structure	Common Name	Eledoisin-Related Peptide TFA
	CAS Number	2990-43-4	Molecular Weight	706.93900
	Density	1.166g/cm3	Boiling Point	1083.4ºC at 760mmHg
	Molecular Formula	C₃₄H₅₈N₈O₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	609ºC

Use of Eledoisin-Related Peptide TFA

Eledoisin Related Peptide is a Substance P analog that excites neurons and triggers behavioral responses. Eledoisin Related Peptide is also a tachykinin receptor ligand.

Name	(2S)-2,6-diamino-N-[(2S)-1-[[(2S,3S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]hexanamide
Synonym	More Synonyms

Description	Eledoisin Related Peptide is a Substance P analog that excites neurons and triggers behavioral responses. Eledoisin Related Peptide is also a tachykinin receptor ligand.
Related Catalog	Signaling Pathways >> Others >> Others Peptides Research Areas >> Neurological Disease
Target	Tachykinin receptor[1]
In Vivo	Eledoisin Related Peptide shares with Substance P (SP) a common N-terminal amino acid sequence and has been shown by to have SP-like activity in the periphery (gut and salivary glands) and the CNS. Eledoisin-related peptide seems to be roughly equipotent with Substance P at identical ejection currents on the single-cell activity of neurons in this nucleus[2]. Both glutamate and substance P (and its analogue, eledoisin-related peptide) have excitatory effects on the activity of respiratory neurons and reflex interneurons[3].
Animal Admin	Rats[2] Twenty-two male albino rats (230-260 g) are anesthetized with chloral hydrate (400 mg/kg, i.p.) and prepared for recording. Briefly, a singlebarrel recording pipette (tip 1 μm) is glued alongside a conventional five-barrel micropipette (tip 15-25/μm) then filled with 2 M NaCI saturated with Fast Green (impedance 4-7 M). The distance between the tip of the recording electrode and that of the five-barrel micropipette is 15-25/zm. Fast Green is ejected at the end of the experiment to identify the recording site. One side barrel of the five-barrel micropipette is loaded with 4 M NaCI for automatic current balancing and the others with three of the following solutions: L-epinephrine bitartrate (0. l M, pH 4.0), L-norepinephrine bitartrate (0.1 M, pH 4.0), Substance P (2.75 mM), physalaemin (2.6 mM), substance P 4-11 octapeptide (3.1 mM), eledoisin-related peptide (20 mM), neurotensin, bradykinin triacetate (15 mM), met-enkephalin (6.5 mM), TRH (48 mM). Spontaneously active cells are recorded in the locus coeruleus or in the nearby mesencephalic nucleus of the fifth nerve whose cells are easily identified by their increased activity upon manipulation of the jaw[2].
References	[1]. Severini C, et al. The tachykinin peptide family. Pharmacol Rev. 2002 Jun;54(2):285-322. [2]. Guyenet PG, et al. Excitation of neurons in the nucleus locus coeruleus by substance P and related peptides. Brain Res. 1977 Nov 4;136(1):178-84. [3]. Henry JL, et al. Effects of glutamate, substance P and eledoisin-related peptide on solitary tract neurones involved in respiration and respiratory reflexes. Neuroscience. 1985 Mar;14(3):863-73.

Density	1.166g/cm3
Boiling Point	1083.4ºC at 760mmHg
Molecular Formula	C₃₄H₅₈N₈O₆S
Molecular Weight	706.93900
Flash Point	609ºC
Exact Mass	706.42000
PSA	265.93000
LogP	4.12680
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.549
Storage condition	2-8℃

Precursor 0
DownStream 4
CAS#:61-90-5 L-leucine CAS#:73-32-5 L-Isoleucine CAS#:4510-08-1 h-met-nh2 CAS#:56-40-6 Glycine

Lysyl-phenylalanyl-isoleucyl-glycyl-leucyl-methioninamide

Lys-Phe-Ile-Gly-Leu-MetNH2

Lpiglm

Lys-phe-ile-gly-leu-met-amide

L-Methioninamide,L-lysyl-L-phenylalanyl-L-isoleucylglycyl-L-leucyl

LYS-PHE-ILE-GLY-LEU-MET-NH2

Eledoisin Related Peptide

GL Biochem (Shanghai) Ltd.
China
Product Name: Eledoisin Related Peptide
Price: $Inquiry/1kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Jackie Yang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Eledoisin Related Peptide
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

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Price: $70/1mg

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