Desfluoro-ezetimibe
Modify Date: 2025-08-25 18:44:56
Desfluoro-ezetimibe structure
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Common Name | Desfluoro-ezetimibe | ||
|---|---|---|---|---|
| CAS Number | 302781-98-2 | Molecular Weight | 391.435 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 642.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C24H22FNO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 342.6±31.5 °C | |
Use of Desfluoro-ezetimibeDesfluoro-ezetimibe is a desfluoro impurity of Ezetimibe. Ezetimibe is a potent, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator[1][2]. |
| Name | (3R,4S)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-1-phenylazetidin-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe. Ezetimibe is a potent, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator[1][2]. |
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| Related Catalog | |
| In Vitro | During the synthetic process development studies of Ezetimibe, an impurity was detected in the final product at levels ranging from 0.05% to 0.15% in reverse phase gradient high performance liquid chromatography (HPLC) method and its molecular weight is determined by LC–MS analysis. The impurity is Desfluoro-ezetimibe[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 642.8±55.0 °C at 760 mmHg |
| Molecular Formula | C24H22FNO3 |
| Molecular Weight | 391.435 |
| Flash Point | 342.6±31.5 °C |
| Exact Mass | 391.158386 |
| PSA | 60.77000 |
| LogP | 3.20 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.635 |
| Hazard Codes | Xi |
|---|
| 2-Azetidinone, 3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-1-phenyl-, (3R,4S)- |
| Desfluoro Ezetimibe |
| (3R,4S)-3-[(3S)-3-(4-Fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-1-phenyl-2-azetidinone |
| Ezetimibe Impurity 8 |