MitoBloCK-6

Modify Date: 2025-08-25 12:46:40

MitoBloCK-6 Structure
MitoBloCK-6 structure
Common Name MitoBloCK-6
CAS Number 303215-67-0 Molecular Weight 357.233
Density 1.3±0.1 g/cm3 Boiling Point 535.1±50.0 °C at 760 mmHg
Molecular Formula C19H14Cl2N2O Melting Point N/A
MSDS N/A Flash Point 277.4±30.1 °C

 Use of MitoBloCK-6


MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC50 of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 (IC50=1.4 μM). MitoBloCK-6 can induce apoptosis via cytochrome c release in hESCs[1].

 Names

Name 2-{(E)-[(4-Anilinophenyl)imino]methyl}-4,6-dichlorophenol
Synonym More Synonyms

 MitoBloCK-6 Biological Activity

Description MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC50 of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 (IC50=1.4 μM). MitoBloCK-6 can induce apoptosis via cytochrome c release in hESCs[1].
Related Catalog
Target

IC50: 900 nM (Erv1) 700 nM (ALR) 1.4 μM (Erv2)[1]

References

[1]. Dabir DV, et, al. A small molecule inhibitor of redox-regulated protein translocation into mitochondria. Dev Cell. 2013 Apr 15;25(1):81-92.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 535.1±50.0 °C at 760 mmHg
Molecular Formula C19H14Cl2N2O
Molecular Weight 357.233
Flash Point 277.4±30.1 °C
Exact Mass 356.048309
LogP 6.34
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.627

 Synonyms

2-{(E)-[(4-Anilinophenyl)imino]methyl}-4,6-dichlorophenol
2,4-Dichloro-6-[(4-phenylamino-phenylimino)-methyl]-phenol
MFCD00557142
Phenol, 2,4-dichloro-6-[(E)-[[4-(phenylamino)phenyl]imino]methyl]-
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