Methyl 5-hydroxypyridine-2-carboxylate

Modify Date: 2024-01-14 11:02:52

Methyl 5-hydroxypyridine-2-carboxylate Structure
Methyl 5-hydroxypyridine-2-carboxylate structure
Common Name Methyl 5-hydroxypyridine-2-carboxylate
CAS Number 30766-12-2 Molecular Weight 153.135
Density 1.3±0.1 g/cm3 Boiling Point 374.2±22.0 °C at 760 mmHg
Molecular Formula C7H7NO3 Melting Point 193.5-195.5℃
MSDS N/A Flash Point 180.1±22.3 °C

 Use of Methyl 5-hydroxypyridine-2-carboxylate


Methyl 5-hydroxypyridine-2-carboxylate is a phenolic acid that can found in the stems of Mahonia fortune. Methyl 5-hydroxypyridine-2-carboxylate exhibits NO inhibitory effects in vitro[1].

 Names

Name methyl 5-hydroxypyridine-2-carboxylate
Synonym More Synonyms

 Methyl 5-hydroxypyridine-2-carboxylate Biological Activity

Description Methyl 5-hydroxypyridine-2-carboxylate is a phenolic acid that can found in the stems of Mahonia fortune. Methyl 5-hydroxypyridine-2-carboxylate exhibits NO inhibitory effects in vitro[1].
Related Catalog
In Vitro Methyl 5-hydroxypyridine-2-carboxylate (compound 2) inhibits NO in LPS-stimulated RAW264.7 and BV2 cells, with IC50s of 115.67 and 118.80 μM, respectively[1]. Methyl 5-hydroxypyridine-2-carboxylate (6.25-200 μM) does not exhibit any cytotoxic effect[1].
References

[1]. Liu L, et, al. Simultaneous characterisation of multiple Mahonia fortunei bioactive compounds in rat plasma by UPLC-MS/MS for application in pharmacokinetic studies and anti-inflammatory activity in vitro. J Pharm Biomed Anal. 2020 Feb 5;179:113013.

[2]. Liu L, et, al. Simultaneous characterisation of multiple Mahonia fortunei bioactive compounds in rat plasma by UPLC-MS/MS for application in pharmacokinetic studies and anti-inflammatory activity in vitro. J Pharm Biomed Anal. 2020 Feb 5;179:113013.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 374.2±22.0 °C at 760 mmHg
Melting Point 193.5-195.5℃
Molecular Formula C7H7NO3
Molecular Weight 153.135
Flash Point 180.1±22.3 °C
Exact Mass 153.042587
PSA 59.42000
LogP 0.82
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.552

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
Product Name: methyl 5-hydroxypyridine-2-carboxylate
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:methyl 5-hydroxypyridine-2-carboxylate
CAS number:30766-12-2

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C7H7NO3
Molecular weight:153.1

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Risk Phrases 20/21/22
Safety Phrases 24/25-36/37
HS Code 2933399090

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

5-Hydroxy-2-(methoxycarbonyl)pyridine
5-Hydroxypyridine-2-carboxylic acid methyl ester
5-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
Methyl 5-hydroxypicolinate
methyl 5-hydroxypyridin-2-carboxylate
Methyl3-hydroxypicolinate
2-Pyridinecarboxylic acid, 5-hydroxy-, methyl ester
Methyl 5-hydroxy-2-pyridinecarboxylate
5-Hydroxy-2-pyridinecarboxylic Acid Methyl Ester
Methyl 5-hydroxypyridine-2-carboxylate
5-Hydroxy-pyridin-2-carbonsaeure-methylester