2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE

Modify Date: 2024-01-10 13:28:32

2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE structure	Common Name	2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE
	CAS Number	312749-73-8	Molecular Weight	304.794
	Density	1.4±0.1 g/cm3	Boiling Point	509.6±56.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₃ClN₂OS	Melting Point	N/A
	MSDS	N/A	Flash Point	262.0±31.8 °C

Use of 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE

CLP-3094 is a potent BF3 (binding function 3)-directed inhibitor of the androgen receptor (AR). CLP-3094 inhibits AR transcriptional activity (IC50=4 μM)[1]. CLP-3094 is a selective, potent GPR142 antagonist[2].

Name	2-{[2-(4-Chlorophenoxy)ethyl]sulfanyl}-1H-benzimidazole
Synonym	More Synonyms

Description	CLP-3094 is a potent BF3 (binding function 3)-directed inhibitor of the androgen receptor (AR). CLP-3094 inhibits AR transcriptional activity (IC50=4 μM)[1]. CLP-3094 is a selective, potent GPR142 antagonist[2].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Signaling Pathways >> Others >> Androgen Receptor
In Vitro	CLP-3094 inhibits both an increase of intracellular Ca2+ concentration ([Ca2+]i) induced by L-tryptophan using CHO-K1 cells expressing GPR142 in the aequorin assay, and an accumulation of inositol phosphates using HEK293 cells expressing GPR142 in the SPA assay. The IC50 of CLP-3094 is 0.2 μM against 200 μM L-tryptophanfor the mouse receptor and 2.3 μM against 1 mM L-tryptophan for the human receptor in the aequorin assay. CLP-3094 also inhibits the insulin secretion from islets induced by both L-tryptophan and GPR142 agonists[2].
In Vivo	CLP-3094 (30, 100 mg/kg; i.p. daily from Day 0 to Day 11) consistently displayed sig-nificantly lower severity of arthritis scores than vehicletreated mice[2]. Animal Model: CAIA mouse model (Female DBA1/J mice were i.v. administered with2 mg of anti-collagen antibody, followed by i.p. administration of 50 μg of LPS)[2] Dosage: 30, 100 mg/kg Administration: I.p. daily from Day 0 to Day 11 Result: Dose-dependently reduced, by not much, the arth-ritis scores.
References	[1]. Munuganti RS, et al. Targeting the binding function 3 (BF3) site of the androgen receptor through virtual screening. 2. development of 2-((2-phenoxyethyl) thio)-1H-benzimidazole derivatives. J Med Chem. 2013;56(3):1136-1148. [2]. Murakoshi M, et al. Discovery and pharmacological effects of a novel GPR142 antagonist. J Recept Signal Transduct Res. 2017;37(3):290-296.

Density	1.4±0.1 g/cm3
Boiling Point	509.6±56.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₃ClN₂OS
Molecular Weight	304.794
Flash Point	262.0±31.8 °C
Exact Mass	304.043701
LogP	5.08
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.693

2-(1H-benzimidazol-2-ylsulfanyl)ethyl 4-chlorophenyl ether

MFCD00805733

1H-Benzimidazole, 2-[[2-(4-chlorophenoxy)ethyl]thio]-

2-{[2-(4-Chlorophenoxy)ethyl]sulfanyl}-1H-benzimidazole

DC Chemicals Limited
China
Product Name: CLP-3094
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥1430/10 mM * 1 mL in DMSO

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2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE

Use of 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE

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