Aristolochic acid A structure
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Common Name | Aristolochic acid A | ||
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CAS Number | 313-67-7 | Molecular Weight | 341.27 | |
Density | 1.6±0.1 g/cm3 | Boiling Point | 615.5±55.0 °C at 760 mmHg | |
Molecular Formula | C17H11NO7 | Melting Point | 260 °C | |
MSDS | Chinese USA | Flash Point | 326.0±31.5 °C | |
Symbol |
GHS06 |
Signal Word | Danger |
Use of Aristolochic acid AAristolochic acid A (Aristolochic acid I) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. AAI significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines[1]. |
Name | aristolochic acid |
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Synonym | More Synonyms |
Description | Aristolochic acid A (Aristolochic acid I) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. AAI significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines[1]. |
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Related Catalog | |
In Vitro | Aristolochic acid A (150, 200 μM, 24 hours) inhibits the cell viabilities of kidney cells HEK293 and HK-2[1]. Aristolochic acid A (100, 200 μM, 24 hours) causes a concentration-dependent decrease in bladder cancer-associated protein (BLCAP) mRNA levels in kidney cells (HEK 293 and HK-2) , and bladder cancer cell line (HT-1376)[1]. Aristolochic acid A (100, 200 μM, 24 hours) weakens the BLCAP protein signals in a dose-dependent manner in both HEK293 and HT-1376 cells[1]. Cell Viability Assay[1] Cell Line: Kidney cells (HEK 293 and HK-2) Concentration: 50, 100, 150, 200 μM Incubation Time: 24 hours Result: The cell viabilities of HEK293 and HK-2 were lower than that of vehicle-treated cultures until 150 μM and 200 μM. RT-PCR[1] Cell Line: Kidney cells (HEK 293 and HK-2), and bladder cancer cell line (HT-1376) Concentration: 100, 200 μM Incubation Time: 24 hours Result: Down regulated the levels of BLCAP mRNA. Western Blot Analysis[1] Cell Line: HEK293 and HT-1376 cells Concentration: 100, 200 μM Incubation Time: 24 hours Result: Reduced the BLCAP protein expression in a dose-dependent manner. |
References |
Density | 1.6±0.1 g/cm3 |
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Boiling Point | 615.5±55.0 °C at 760 mmHg |
Melting Point | 260 °C |
Molecular Formula | C17H11NO7 |
Molecular Weight | 341.27 |
Flash Point | 326.0±31.5 °C |
Exact Mass | 341.053558 |
PSA | 110.81000 |
LogP | 3.41 |
Vapour Pressure | 0.0±1.9 mmHg at 25°C |
Index of Refraction | 1.747 |
Water Solubility | DMSO: soluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H301 |
Precautionary Statements | P301 + P310 |
Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
Hazard Codes | T:Toxic |
Risk Phrases | R25 |
Safety Phrases | S7-S35-S45 |
RIDADR | UN 1544 6.1/PG 3 |
WGK Germany | 3 |
RTECS | CF3325000 |
Packaging Group | III |
Hazard Class | 6.1(b) |
Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway.
Toxicology 318 , 22-31, (2014) Bardoxolone methyl (BARD) is an antioxidant modulator that acts through induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. This study aimed to investigate the role ... |
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Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor.
Int. J. Mol. Sci. 16 , 16454-68, (2015) Exposure to aristolochic acid I (AAI) can lead to aristolochic acid nephropathy (AAN), Balkan endemic nephropathy (BEN) and urothelial cancer. The induction of hepatic CYP1A, especially CYP1A2, was co... |
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Association of blood lead and mercury with estimated GFR in herbalists after the ban of herbs containing aristolochic acids in Taiwan.
Occup. Environ. Med. 70(8) , 545-51, (2013) This study was undertaken to explore the association of estimated glomerular filtration rate (GFR) with exposure to aristolochic acids (ALAs) and nephrotoxic metals in herbalists after the ban of herb... |
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