o-3M3FBS

Modify Date: 2024-06-29 20:06:13

o-3M3FBS Structure
o-3M3FBS structure
Common Name o-3M3FBS
CAS Number 313981-55-4 Molecular Weight 343.36400
Density 1.316g/cm3 Boiling Point 424.3ºC at 760mmHg
Molecular Formula C16H16F3NO2S Melting Point N/A
MSDS N/A Flash Point 210.4ºC

 Use of o-3M3FBS


o-3M3FBS is the negative control of m-3M3FBS. o-3M3FBS inhibits inward and outward currents via mechanisms independent of PLC acting in an antagonistic manner. In contrast, o-3M3FBS also causes an increase in [Ca2+]i in an agonistic manner[1].

 Names

Name 2,4,6-trimethyl-N-[2-(trifluoromethyl)phenyl]benzenesulfonamide
Synonym More Synonyms

 o-3M3FBS Biological Activity

Description o-3M3FBS is the negative control of m-3M3FBS. o-3M3FBS inhibits inward and outward currents via mechanisms independent of PLC acting in an antagonistic manner. In contrast, o-3M3FBS also causes an increase in [Ca2+]i in an agonistic manner[1].
Related Catalog
In Vivo o-3M3FBS (10 μM) decreases AUC from 1058±189 g/min in control (in the presence of TTX) to 840±134 g/min. Higher concentration of o-3M3FBS (25 μM) further decreases AUC to 457±59 g/min[1].
References

[1]. Dwyer L, et al. Phospholipase C-independent effects of 3M3FBS in murine colon. Eur J Pharmacol. 2010;628(1-3):187-194.

 Chemical & Physical Properties

Density 1.316g/cm3
Boiling Point 424.3ºC at 760mmHg
Molecular Formula C16H16F3NO2S
Molecular Weight 343.36400
Flash Point 210.4ºC
Exact Mass 343.08500
PSA 54.55000
LogP 5.58520
Index of Refraction 1.547

 Synonyms

HMS3268M14
O-3M3FBS
Tocris-1942
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