Moroxydine (hydrochloride)

Modify Date: 2024-01-01 19:08:49

Moroxydine (hydrochloride) Structure
Moroxydine (hydrochloride) structure
 Common Name Moroxydine (hydrochloride)
CAS Number 3160-91-6 Molecular Weight 207.661
Density N/A Boiling Point 327ºC at 760 mmHg
Molecular Formula C6H14ClN5O Melting Point 211-214ºC(lit.)
MSDS N/A Flash Point 151.6ºC

 Use of Moroxydine (hydrochloride)


Moroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.Target: Influenza VirusMoroxydine is an antiviral drug that was originally developed in the 1950s as an influenza treatment. It has potential applications against a number of RNA and DNA viruses [1]. Structurally moroxydine is a heterocyclic biguanidine. Moroxydine was reported in March 2014 that three kindergartens in two provinces of China had been found to be secretly dosing their students with moroxydine hydrochloride to try to prevent them from becoming ill. The kindergartens are paid only for the days that pupils attend and wanted to ensure that they maximised their earnings [2].

 Names

Name moroxydine hydrochloride
Synonym More Synonyms

 Moroxydine (hydrochloride) Biological Activity

Description Moroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.Target: Influenza VirusMoroxydine is an antiviral drug that was originally developed in the 1950s as an influenza treatment. It has potential applications against a number of RNA and DNA viruses [1]. Structurally moroxydine is a heterocyclic biguanidine. Moroxydine was reported in March 2014 that three kindergartens in two provinces of China had been found to be secretly dosing their students with moroxydine hydrochloride to try to prevent them from becoming ill. The kindergartens are paid only for the days that pupils attend and wanted to ensure that they maximised their earnings [2].
Related Catalog
References

[1]. Sheppard, S., Moroxydine: the story of a mislaid antiviral. Acta Derm Venereol Suppl (Stockh), 1994. 183: p. 1-9.

[2]. Moore, Malcolm. "China: All children to be given drug tests after schools caught medicating pupils". The Age. Retrieved 2014-03-20.

 Chemical & Physical Properties

Boiling Point 327ºC at 760 mmHg
Melting Point 211-214ºC(lit.)
Molecular Formula C6H14ClN5O
Molecular Weight 207.661
Flash Point 151.6ºC
Exact Mass 207.088684
PSA 98.22000
LogP 0.76700

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QD9815000
CHEMICAL NAME :
4-Morpholinecarboxamidine, N-amidino-, monohydrochloride
CAS REGISTRY NUMBER :
3160-91-6
LAST UPDATED :
199501
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C6-H13-N5-O.Cl-H
MOLECULAR WEIGHT :
207.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>6250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 18,196,1965
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
325 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26-37/39
WGK Germany 3
RTECS QD9815000
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Moroxydine (hydrochloride)
4-Morpholinecarboximidoylguanidine Hydrochloride
abobhydrochloride
Moroxydine hydrochlorid
Hydrogen chloride - N-carbamimidoyl-4-morpholinecarboximidamide (1:1:1)
N-Carbamimidoyl-4-morpholinecarboximidamide chlorhydrate (1:1)
assur
Moroxydine hydrochloride
4-Morpholinecarboximidamide, N-(aminoiminomethyl)-, chloride, hydrogen salt (1:1)
N-Carbamimidoyl-4-morpholincarboximidamidhydrochlorid(1:1)
N1,N1-Anhydrobis(b-hydroxyethyl)biguanide Hydrochloride
N,N-oxapentamethylenebiguanide hydrochloride
virusmin
N-Carbamimidoyl-4-morpholinecarboximidamide hydrochloride
virustat
N1-morpholinobiguanidine hydrochloride
Miejunging
N-amidino-4-morpholincarboxamidine*hydrochloride
Malinguchlorate
Abitilguanide Hydrochloride
flumidin
1-Morpholinobiguanide Hydrochloride
N-(aminoiminomethyl)-4-morpholinecarboximidamide hydrochloride (1:1)
4-Morpholinecarboximidamide, N- (aminoiminomethyl)-, monohydrochloride
morpholinebiguanide monohydrochloride
spenitol
N-carbamimidoylmorpholine-4-carboximidamide hydrochloride
MORPHOLINO-BIUANIDE HYDROCHLORIDE
MOROXYDINE HCL
Abitylguanide Hydrochloride
N-Carbamimidoylmorpholine-4-carboximidamide hydrochloride (1:1)
morpholinebiguanidine hydrochloride
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