[D-Trp8]-γ-MSH

Modify Date: 2024-01-13 15:22:04

[D-Trp8]-γ-MSH structure	Common Name	[D-Trp8]-γ-MSH
	CAS Number	321351-81-9	Molecular Weight	1570.774
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₇₄H₉₉N₂₁O₁₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of [D-Trp8]-γ-MSH

[D-Trp8]-γ-MSH is a potent and selective agonist of melanocortin 3 (MC3) receptor, with IC50s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4 and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis[1][2].

Name	(D-Trp8)-γ2-MSH trifluoroacetate salt
Synonym	More Synonyms

Description	[D-Trp8]-γ-MSH is a potent and selective agonist of melanocortin 3 (MC3) receptor, with IC50s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4 and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor
Target	melanocortin 3 (MC3) receptor[1]
References	[1]. Grieco P, et, al. D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity. J Med Chem. 2000 Dec 28; 43(26): 4998-5002. [2]. Kadiri JJ, et, al. Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice. Eur J Pharmacol. 2020 Aug 5; 880:173186.

Density	1.5±0.1 g/cm3
Molecular Formula	C₇₄H₉₉N₂₁O₁₆S
Molecular Weight	1570.774
Exact Mass	1569.729980
LogP	1.27
Index of Refraction	1.685

L-Tyrosyl-L-valyl-L-methionylglycyl-L-histidyl-L-phenylalanyl-L-arginyl-D-tryptophyl-L-α-aspartyl-L-arginyl-L-phenylalanylglycine

L-tyrosyl-L-valyl-L-methionylglycyl-L-histidyl-L-phenylalanyl-N5-(diaminomethylidene)-L-ornithyl-D-tryptophyl-L-α-aspartyl-N5-(diaminomethylidene)-L-ornithyl-L-phenylalanylglycine

Glycine, L-tyrosyl-L-valyl-L-methionylglycyl-L-histidyl-L-phenylalanyl-L-arginyl-D-tryptophyl-L-α-aspartyl-L-arginyl-L-phenylalanyl-

DC Chemicals Limited
China
Product Name: [D-Trp8]-γ-MSH
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Taiwan Oyi peptide Co. Ltd
China
Product Name: [D-TRP8]-Γ-MSH
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Vinnie

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