Cytosporone B
Modify Date: 2025-08-25 17:35:41
Cytosporone B structure
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Common Name | Cytosporone B | ||
|---|---|---|---|---|
| CAS Number | 321661-62-5 | Molecular Weight | 322.39600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H26O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Cytosporone BCytosporone B (Csn-B;Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77 agonist with an EC50 of 0.278 nM. |
| Name | ethyl 2-(3,5-dihydroxy-2-octanoylphenyl)acetate |
|---|---|
| Synonym | More Synonyms |
| Description | Cytosporone B (Csn-B;Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77 agonist with an EC50 of 0.278 nM. |
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| Related Catalog | |
| Target |
EC50: 0.278 nM (Nur77)[1] |
| In Vitro | Cytosporone B targets the ligand binding domain of Nur77, which selectively stimulates the transactivational activity of Nur77. Cytosporone B induces luciferase activity in cells that are cotransfected with GAL4- Nur77 or GAL4-LBD. The EC50 of cytosporone B for Nur77 is 0.278 nM. Cytosporone B displays robust pro-apoptotic activity in gastric cancer cells BGC-823. 63.5% of the cells are apoptotic when treated with cytosporone B for 48 h. Cytosporone B shows selective effect on cancerous cells. Cytosporone B inhibits proliferation of human gastric cancer BGC-823 cells and human colon cancer SW620 cells by 470%, but it has a modest effect on human lung cancer H1299 cells and human hepatoma HepG2 cells[1]. |
| In Vivo | In the hepatocytes of wild-type mice, the transcriptional activity of the reporter is induced five-fold with cytosporone B treatment. In wild-type mice, cytosporone B treatment significantly increases glucose levels from 3.2 to 11.4 mM within the first 30 min, and thereafter blood glucose gradually decreased before reaching the initial level after 300 min[1]. |
| Cell Assay | Human gastric cancer BGC-823 cells and human colon cancer SW620 cells are treated with cytosporone B for 72 h at 0-15 μg/mL. Cell viability is measured using the MTT assay[1]. |
| Animal Admin | Mice: The inoculated mice are randomly separated into two groups. One group is given an injection to the abdominal cavity at a dosage of 13 mg/kg of cytosporone B twice a week. The other group is administered with DMSO without cytosporone B. Food consumption and body weight of nude mice are monitored weekly. Four weeks later, the nude mice are killed and the tumors formed are removed, fixed and embedded[1]. |
| References |
| Molecular Formula | C18H26O5 |
|---|---|
| Molecular Weight | 322.39600 |
| Exact Mass | 322.17800 |
| PSA | 83.83000 |
| LogP | 3.74660 |
| Storage condition | 2-8℃ |
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NUR77 exerts a protective effect against inflammatory bowel disease by negatively regulating the TRAF6/TLR-IL-1R signalling axis.
J. Pathol. 238 , 457-69, (2016) Nur77, an immediate-early response gene, participates in a wide range of biological functions. Its human homologue, NUR77, is known by several names and has the HGNC-approved gene symbol NR4A1. Howeve... |
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Histone acetylation regulates orphan nuclear receptor NR4A1 expression in hypercholesterolaemia.
Clin. Sci. (Lond.) 129 , 1151-61, (2015) Hypercholesterolaemia and inflammation are correlated with atherogenesis. Orphan nuclear receptor NR4A1, as a key regulator of inflammation, is closely associated with lipid levels in vivo. However, t... |
| 3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester |
| Csn-B |
| Benzeneacetic acid,3,5-dihydroxy-2-(1-oxooctyl)-,ethyl ester |
| CYTOSPORONE B |