L002
Modify Date: 2024-01-02 17:52:32
L002 structure
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Common Name | L002 | ||
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| CAS Number | 321695-57-2 | Molecular Weight | 321.348 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 459.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C15H15NO5S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 231.9±31.5 °C | |
Use of L002L002 is a novel potent, specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 uM. L002 has weak inhibitory effects against PCAF and GCN5 (IC50s =35 and 34 µM, respectively) and is specific for p300 over a panel of additional acetyltransferases, deacetylases, and methyltransferases[1]. L002 blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation[2]. |
| Name | 4-({[(4-Methoxyphenyl)sulfonyl]oxy}imino)-2,6-dimethyl-2,5-cyclohexadien-1-one |
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| Synonym | More Synonyms |
| Description | L002 is a novel potent, specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 uM. L002 has weak inhibitory effects against PCAF and GCN5 (IC50s =35 and 34 µM, respectively) and is specific for p300 over a panel of additional acetyltransferases, deacetylases, and methyltransferases[1]. L002 blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation[2]. |
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| Related Catalog | |
| Target |
IC50: 1.98 uM (KAT3B); 35 µM (PCAF); 34 µM (GCN5)[1] ;STAT3; p53[2] |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 459.8±55.0 °C at 760 mmHg |
| Molecular Formula | C15H15NO5S |
| Molecular Weight | 321.348 |
| Flash Point | 231.9±31.5 °C |
| Exact Mass | 321.067108 |
| LogP | 4.06 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.574 |
| RIDADR | NONH for all modes of transport |
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| 4-({[(4-Methoxyphenyl)sulfonyl]oxy}imino)-2,6-dimethyl-2,5-cyclohexadien-1-one |
| 4-({[(4-Methoxyphenyl)sulfonyl]oxy}imino)-2,6-dimethylcyclohexa-2,5-dien-1-one |
| L002 |