321695-57-2

321695-57-2 structure

Name: L002
Chemical Name: 4-({[(4-Methoxyphenyl)sulfonyl]oxy}imino)-2,6-dimethyl-2,5-cyclohexadien-1-one
CAS Number: 321695-57-2
Molecular Formula: C₁₅H₁₅NO₅S
Molecular Weight: 321.348
Catalog: Signaling Pathways Epigenetics Histone Acetyltransferase
Create Date: 2018-02-18 22:30:48
Modify Date: 2024-01-02 17:52:32
L002 is a novel potent, specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 uM. L002 has weak inhibitory effects against PCAF and GCN5 (IC50s =35 and 34 µM, respectively) and is specific for p300 over a panel of additional acetyltransferases, deacetylases, and methyltransferases[1]. L002 blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation[2].

Name	4-({[(4-Methoxyphenyl)sulfonyl]oxy}imino)-2,6-dimethyl-2,5-cyclohexadien-1-one
Synonyms	4-({[(4-Methoxyphenyl)sulfonyl]oxy}imino)-2,6-dimethyl-2,5-cyclohexadien-1-one 4-({[(4-Methoxyphenyl)sulfonyl]oxy}imino)-2,6-dimethylcyclohexa-2,5-dien-1-one L002

Description	L002 is a novel potent, specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 uM. L002 has weak inhibitory effects against PCAF and GCN5 (IC50s =35 and 34 µM, respectively) and is specific for p300 over a panel of additional acetyltransferases, deacetylases, and methyltransferases[1]. L002 blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation[2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> Epigenetics >> Histone Acetyltransferase
Target	IC50: 1.98 uM (KAT3B); 35 µM (PCAF); 34 µM (GCN5)[1] ;STAT3; p53[2]
References	[1]. Rai R, et al. A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis. Epigenetics. 2017;12(11):1004-1013. [2]. Sun XJ, et al. The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis. Front Oncol. 2015 May 26;5:108.

RIDADR	NONH for all modes of transport