ZnAF-2
Modify Date: 2025-08-27 14:53:21
ZnAF-2 structure
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Common Name | ZnAF-2 | ||
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| CAS Number | 321859-11-4 | Molecular Weight | 572.61000 | |
| Density | 1.44g/cm3 | Boiling Point | 847.8ºC at 760 mmHg | |
| Molecular Formula | C34H28N4O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 466.5ºC | |
Use of ZnAF-2ZnAF-2, 6-iso- is a cell-impermeable compound that acts as a high-affinity Zn2?-specific fluorescent probe (Kd = 2.7 nM). It exhibits low basal fluorescence with an approximately 51-fold increase in fluorescence intensity upon stoichiometric (1:1) binding to Zn2?. Little affinity for Ca2?, Mg2?, Na? or K?. |
| Name | 4-[2-[bis(pyridin-2-ylmethyl)amino]ethylamino]-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid |
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| Synonym | More Synonyms |
| Description | ZnAF-2, 6-iso- is a cell-impermeable compound that acts as a high-affinity Zn2?-specific fluorescent probe (Kd = 2.7 nM). It exhibits low basal fluorescence with an approximately 51-fold increase in fluorescence intensity upon stoichiometric (1:1) binding to Zn2?. Little affinity for Ca2?, Mg2?, Na? or K?. |
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| Related Catalog |
| Density | 1.44g/cm3 |
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| Boiling Point | 847.8ºC at 760 mmHg |
| Molecular Formula | C34H28N4O5 |
| Molecular Weight | 572.61000 |
| Flash Point | 466.5ºC |
| Exact Mass | 572.20600 |
| PSA | 128.79000 |
| LogP | 5.94590 |
| Index of Refraction | 1.737 |
| InChIKey | CORIVNRIBACDOQ-UHFFFAOYSA-N |
| SMILES | O=C(O)c1ccc(NCCN(Cc2ccccn2)Cc2ccccn2)cc1-c1c2ccc(=O)cc-2oc2cc(O)ccc12 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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Improvement and biological applications of fluorescent probes for zinc, ZnAFs.
J. Am. Chem. Soc. 124 , 6555-6562, (2002) The development and cellular applications of novel fluorescent probes for Zn2+, ZnAF-1F, and ZnAF-2F are described. Fluorescein is used as a fluorophore of ZnAFs, because its excitation and emission w... |
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Hirano, T., et al.
J. Am. Chem. Soc. 122 , 12399-12400 , (2000)
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| 6-{2-[Bis(2-pyridylmethyl)amino]ethylamino}fluorescein |