PTP Inhibitor IV

Modify Date: 2025-08-20 14:19:06

PTP Inhibitor IV structure	Common Name	PTP Inhibitor IV
	CAS Number	329317-98-8	Molecular Weight	608.616
	Density	1.4±0.1 g/cm3	Boiling Point	578.0±60.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₂₆F₆N₂O₄S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	303.4±32.9 °C

Use of PTP Inhibitor IV

PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an 50 of 5.21 μM[1]. PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with 50s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively[2].

Name	PTP Inhibitor IV
Synonym	More Synonyms

Description	PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an 50 of 5.21 μM[1]. PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with 50s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Target	IC50: 1.8 μM (SHP-2), 2.5 μM (PTP1B), 8.4 μM (PTP-ε), 13 μM (PTP Meg-2), 20 μM (PTP-σ), 6.4 μM (PTP-β), and 6.7 μM (PTP-μ)[2]; 5.21 μM (DUSP14)[1]
In Vitro	PTP Inhibitor IV 通过结合在催化位点下调 DUSP14 的催化活性[1]。 PTP Inhibitor IV（0-100 μM；3 小时）有效且特异性地抑制 DUSP14 介导的 JNK 去磷酸化[1]。 Western Blot Analysis[1] Cell Line: HEK 293 cells Concentration: 0, 10 μM, 50 μM, or 100 μM Incubation Time: 3 hours Result: Effectively penetrated the cells and inhibited DUSP14 activity.
References	[1]. Jae Eun Park, et al. PTP inhibitor IV protects JNK kinase activity by inhibiting dual-specificity phosphatase 14 (DUSP14). Biochem Biophys Res Commun. 2009 Oct 2;387(4):795-9. [2]. Ping Huang, et al. Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases. Bioorg Med Chem. 2003 Apr 17;11(8):1835-49.

Density	1.4±0.1 g/cm3
Boiling Point	578.0±60.0 °C at 760 mmHg
Molecular Formula	C₂₆H₂₆F₆N₂O₄S₂
Molecular Weight	608.616
Flash Point	303.4±32.9 °C
Exact Mass	608.123840
LogP	9.41
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.560
Storage condition	2-8°C

Methanesulfonamide, N,N'-[1,4-phenylenebis[(1-methylethylidene)-4,1-phenylene]]bis[1,1,1-trifluoro-

N,N'-[1,4-Phenylenebis(2,2-propanediyl-4,1-phenylene)]bis(1,1,1-trifluoromethanesulfonamide)

PTP Inhibitor IV

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PTP Inhibitor IV
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: PTP Inhibitor IV
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.